The effect of ascorbic acid on urine pH was studied in spinal cord injury patients. Their urine was not colonized by urease positive microorganisms. The study was designed to compare the baseline urine pH value and the urine pH value after the administration of placebo or ascorbic acid 500 mg/6 h. The diet and medical treatment were not controlled. A significant decrease in urine pH value was not obtained. There was no clinical benefit from the use of ascorbic acid.
Sobel J D, Kaye D . Urinary tract infection. In: Mandell GL, Douglas RG, Bennett JE, ed. Principles and Practice of Infectious Diseases. 3rd ed. John Whiley & Sons, Inc., 1990.
Drug Information for the Health Care Provider. USP DI. Seventh Edition 1987. The United States Pharmacopeial Convection, Inc.
Girona L, et al. Efectividad del ácido ascórbico como acidificante urinario en pacientes con vejiga neurógena por lesión medular. Urod A 1990; 2: 91–94.
Hetey S K, et al. Effect of ascorbic acid on urine pH in patients with injured spinal cords. Am J Hosp Pharm 1980; 37: 235–237.
Murphy F J, Zelman S, Mau W . Ascorbic acid as a urinary acidifying agent: 2. Its adjunctive role in chronic urinary infection. J Urol 1965; 94: 300–303.
Nahata M C, Shimp L, Lampman T, McLeod D C . Effect of ascorbic acid on urine pH in man. Am J Hosp Pharm 1977; 34: 1234–1237.
Muiznieks V E . Effect of oral vitamin Conurine pH. Can J Hosp Pharm 1978; 31: 18–22.
Barton C H, et al. Ineffectiveness of intravenous ascorbic acid as an acidifying agent in man. Arch Intern Med 1981; 141: 211–212.
Bannwart C, et al. Beeinflussung des Urin-pH durch Ascorbinsäure. Helv Chir Acta 1981; 48: 425–428.
Garner J S, et al. CDC definitions for nosocomial infections. Am J Infect Control 1988; 16: 128–140.
Gibaldi M, Grundhofer B, Levy G . Effect of antiacids on pH urine. Clin Pharmacol Ther 1974; 16: 520–525.
Rights and permissions
About this article
Cite this article
Castelló, T., Girona, L., Gómez, M. et al. The possible value of ascorbic acid as a prophylactic agent for urinary tract infection. Spinal Cord 34, 592–593 (1996). https://doi.org/10.1038/sc.1996.105
- ascorbic acid
- urinary acidifying agent
- urinary tract infection
- spinal cord injured patients
This article is cited by
Systematic review: bacterial colonisation of conduits and neobladders—when to test, watch, and treat
World Journal of Urology (2020)
Nonantibiotic prevention and management of recurrent urinary tract infection
Nature Reviews Urology (2018)
Neurogenic Bladder: Recurrent Urinary Tract Infections—Beyond Antibiotics
Current Bladder Dysfunction Reports (2018)
Prevention of Urinary Tract Infection for Patients with Neurogenic Bladder
Current Bladder Dysfunction Reports (2014)
Reply to the letter from H. Kalhoff
Pediatric Nephrology (2004)