Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Neuropsychiatric disorders

Brain functional connectivity abnormalities in trauma-related dissociation

Nature Mental Health volume 1, pages 704–706 (2023)Cite this article

Subjects

Some individuals with post-traumatic stress disorder (PTSD) experience a series of symptoms attributable to ‘dissociation’ — severance either with themselves or their surroundings. A new study on the neurobiology of dissociation in PTSD uses functional MRI analysis to identify unique patterns of brain–behavior associations.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Finding alignment between subtyping strategies.

References

  1. Galatzer-Levy, I. R. & Bryant, R. A. Perspect. Psychol. Sci. 8, 651–662 (2013).

    Article  PubMed  Google Scholar 

  2. Lanius, R. A., Brand, B., Vermetten, E., Frewen, P. A. & Spiegel, D. Depress. Anxiety 29, 701–708 (2012).

    Article  PubMed  Google Scholar 

  3. Shaw, S. B. et al. Nat. Mental Health https://doi.org/10.1038/s44220-023-00115-y (2023).

    Article  Google Scholar 

  4. Lebois, L. A. M. et al. Neuropsychopharmacol. 47, 2261–2270 (2022).

    Article  Google Scholar 

  5. Stevens, J. S. et al. Am. J. Psychiatry 178, 1037–1049 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Yang, R. et al. Mol. Psychiatry 26, 4300–4314 (2021).

    Article  PubMed  Google Scholar 

  7. Goodman, M., New, A. & Siever, L. Ann. N. Y. Acad. Sci. 1032, 104–116 (2004).

    Article  PubMed  Google Scholar 

  8. Dalvie, S. et al. Neurobiol. Stress 15, 100393 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Vesuna, S. et al. Nature 586, 87–94 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Dorahy, M. J. & van der Hart, O. J. Trauma Dissociation 16, 7–28 (2015).

    Article  PubMed  Google Scholar 

  11. Friedman, M. J. J. Trauma Stress 26, 548–556 (2013).

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

This work was supported by NIMH (R21-MH121909 to N.P.D.).

Author information

Authors and Affiliations

  1. McLean Hospital, Belmont, MA, USA

    Athina R. Aruldass & Nikolaos P. Daskalakis

  2. Department of Psychiatry, Harvard Medical School, Boston, MA, USA

    Athina R. Aruldass & Nikolaos P. Daskalakis

  3. Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA

    Athina R. Aruldass & Nikolaos P. Daskalakis

Authors
  1. Athina R. Aruldass
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nikolaos P. Daskalakis
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nikolaos P. Daskalakis.

Ethics declarations

Competing interests

N.P.D. has served on scientific advisory boards for BioVie Pharma, Circular Genomics and Sentio Solutions for unrelated work. A.R.A. declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Aruldass, A.R., Daskalakis, N.P. Brain functional connectivity abnormalities in trauma-related dissociation. Nat. Mental Health 1, 704–706 (2023). https://doi.org/10.1038/s44220-023-00132-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s44220-023-00132-x

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing