By integrating neuroimaging and multi-omics data, we established links between individual genetic variations and macro- to microscale brain circuit dysfunctions, specifically in corticocortical and corticostriatal circuits, that contribute to the diverse clinical manifestations of schizophrenia. These findings advance our understanding of the disease’s heterogeneity and offer potential treatment insights.
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References
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This is a summary of: Wang, M. et al. Neuroimaging and multiomics reveal crossscale circuit abnormalities in schizophrenia. Nat. Ment. Health https://doi.org/10.1038/s44220-023-00110-3 (2023).
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Bridging the cross-scale heterogeneity of schizophrenia. Nat. Mental Health 1, 611–612 (2023). https://doi.org/10.1038/s44220-023-00117-w
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DOI: https://doi.org/10.1038/s44220-023-00117-w
