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CARDIAC HYPERTROPHY

Piezo1 links mechanosensation to cardiac growth

Nature Cardiovascular Research volume 1, pages 533–534 (2022)Cite this article

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The stretch-activated ion channel Piezo1 senses biomechanical stress and provides calcium for transcriptional activation and cardiac growth. In turn, the high amplitude of calcium determines specific signaling through the CaMKII–HDAC–MEF2 pathway as opposed to the calcineurin–NFAT pathway.

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Fig. 1: A role for Piezo1 in cardiac growth.

References

  1. Narloch, J. A. & Brandstater, M. E. Arch. Phys. Med. Rehabil. 76, 457–462 (1995).

    Article  CAS  Google Scholar 

  2. Frey, N. & Olson, E. N. Annu. Rev. Physiol. 65, 45–79 (2003).

    Article  CAS  Google Scholar 

  3. Backs, J. et al. J. Clin. Invest. 116, 1853–1864 (2006).

    Article  CAS  Google Scholar 

  4. Molkentin, J. D. et al. Cell 93, 215–228 (1998).

    Article  CAS  Google Scholar 

  5. Lahiri, S. K. et al. Pflugers Arch. 473, 331–347 (2021).

    Article  CAS  Google Scholar 

  6. Yu, Z.-Y. et al. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-022-00082-0 (2022).

    Article  PubMed  Google Scholar 

  7. Coste, B. et al. Science 330, 55–60 (2010).

    Article  CAS  Google Scholar 

  8. Ling, H. et al. J. Clin. Invest. 119, 1230–1240 (2009).

    Article  CAS  Google Scholar 

  9. Kreusser, M. M. et al. Circulation 130, 1262–1273 (2014).

    Article  CAS  Google Scholar 

  10. MacDonnell, S. M. et al. Circ. Res. 105, 316–325 (2009).

    Article  CAS  Google Scholar 

  11. Nickel, A. G. et al. Cell Metab. 22, 472–484 (2015).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Institute of Experimental Cardiology, Heidelberg University, Heidelberg, Germany

    Johannes Backs

  2. German Center for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany

    Johannes Backs

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  1. Johannes Backs
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Correspondence to Johannes Backs.

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Competing interests

J.B. is a scientific co-founder of Artemis Bio and collaborates with the LDC Dortmund and Novo Nordisk to develop CaMKII-HDAC4 inhibitory compounds.

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Backs, J. Piezo1 links mechanosensation to cardiac growth. Nat Cardiovasc Res 1, 533–534 (2022). https://doi.org/10.1038/s44161-022-00084-y

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