Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

SYSTEMS BIOLOGY

Functional change along cellular trajectories

The identification of genes that are associated with developmental trajectories of cells is an important focus in single-cell transcriptomics. This issue presents Scellnetor, a resource that facilitates this task.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Scellnetor enables the integration of protein interaction networks with cellular trajectories in transcriptional space to reveal the functional modules that are associated with these trajectories.

References

  1. Svensson, V., Vento-Tormo, R. & Teichmann, S. A. Nat. Protoc. 13, 599–604 (2018).

    Article  Google Scholar 

  2. Grønning, A. G. B. et al. Nat. Comput. Sci. https://doi.org/10.1038/s43588-021-00025-y (2021).

  3. Campbell, K. R. & Yau, C. Bioinformatics 33, 1241–1242 (2017).

    Google Scholar 

  4. Stark, C. et al. Nucl. Acids Res. 34, D535–D539 (2006).

    Article  Google Scholar 

  5. Lewis, A. C. F., Jones, N. S., Porter, M. A. & Deane, C. M. BMC Sys. Biol. 4, 100 (2010).

    Article  Google Scholar 

  6. Ji, J., Zhang, A., Liu, C., Quan, X. & Liu, Z. IEEE Trans. Knowledge Data Eng. 26, 261–277 (2012).

    Article  Google Scholar 

  7. Klimm, F. et al. BMC Genom. 21, 756 (2020).

    Article  Google Scholar 

  8. Choobdar, S. et al. Nat. Methods 16, 843–852 (2019).

    Article  Google Scholar 

  9. Paul, F. et al. Cell 163, 1663–1677 (2015).

    Article  Google Scholar 

  10. Becht, E. et al. Nat. Biotechnol. 37, 38–44 (2019).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Florian Klimm.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Klimm, F. Functional change along cellular trajectories. Nat Comput Sci 1, 102–103 (2021). https://doi.org/10.1038/s43588-021-00026-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s43588-021-00026-x

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing