Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Epigenetics of aging

Slow and steady lives the longest

Nature Aging volume 4, pages 7–9 (2024)Cite this article

Subjects

Two recent studies discover a scaling law of mammalian lifespans: the speed at which DNA methylation drifts from a youthful state strongly associates with maximum lifespan.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: The rate at which DNA methylation drifts from a youthful state scales with lifespan.

References

  1. West, G. B. & Brown, J. H. J. Exp. Biol. 208, 1575–1592 (2005).

    Article  PubMed  Google Scholar 

  2. Crofts, S. J. C., Latorre-Crespo, E. & Chandra, T. Nat. Aging https://doi.org/10.1038/s43587-023-00535-6 (2023).

    Article  PubMed  Google Scholar 

  3. Horvath, S., Zhang, J., Haghani, A. & Fei, Z. Preprint at bioRxiv, https://doi.org/10.1101/2023.05.21.541643 (2023).

  4. Booth, L. N. & Brunet, A. Mol. Cell 62, 728–744 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Hannum, G. et al. Mol. Cell 49, 359–367 (2013).

    Article  CAS  PubMed  Google Scholar 

  6. Horvath, S. Genome Biol. 14, 3156 (2013).

    Article  Google Scholar 

  7. Lu, A. T. et al. Nat. Aging 3, 1144–1166 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Lowe, R. et al. Genome Biol. 19, 22 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Wilkinson, G. S. et al. Nat. Commun. 12, 1615 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Bertucci-Richter, E. M. & Parrott, B. B. Nat. Commun. 14, 7731 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Cagan, A. et al. Nature 604, 517–524 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Moqri, M. et al. Preprint at bioRxiv, https://doi.org/10.1101/2022.06.03.494609 (2022).

  13. Rakyan, V. K. et al. Genome Res. 20, 434–439 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Tian, X. et al. Cell 177, 622–638.e22 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

Research in the authors’ laboratories is supported by grants from the US National Institutes on Aging (A.S. and V.G.), the Milky Way Foundation, Michael Antonov Foundation, Impetus grant (V.G.).

Author information

Authors and Affiliations

  1. Department of Biology, University of Rochester, Rochester, NY, USA

    Francesco Morandini, Andrei Seluanov & Vera Gorbunova

  2. Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA

    Andrei Seluanov & Vera Gorbunova

Authors
  1. Francesco Morandini
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Andrei Seluanov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Vera Gorbunova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Vera Gorbunova.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Morandini, F., Seluanov, A. & Gorbunova, V. Slow and steady lives the longest. Nat Aging 4, 7–9 (2024). https://doi.org/10.1038/s43587-023-00554-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s43587-023-00554-3

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing