Oleson et al. tackle the enduring question of the extent to which transient events during development shape our outcomes by studying the effects of early-life exposure to oxidative stress. They find that a cascade of changes initiated by the epigenetic-modifier COMPASS complex manifests in rearrangements in lipid metabolism in adulthood, which confers broad protection against amyloid-induced proteotoxicity.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Oleson, B. J. et al. Nat. Aging https://doi.org/10.1038/s43587-023-00537-4 (2023).
Knoefler, D. et al. Mol. Cell 47, 767–776 (2012).
Bazopoulou, D. et al. Nature 576, 301–305 (2019).
Volovik, Y. et al. Aging Cell 11, 491–499 (2012).
Steinkraus, K. A. et al. Aging Cell 7, 394–404 (2008).
Srinivasan, S. et al. Cell Metab. 7, 533–544 (2008).
Bouagnon, A. D. et al. PLoS Biol. 17, e3000242 (2019).
Srinivasan, S. Annu. Rev. Physiol. 77, 161–178 (2015).
Cao, Q. et al. Sci. Adv. 6, eabc8096 (2020).
Acknowledgements
S.S. is supported in part by research grants to S.S. from the NIH/NIDDK (R01 DK124706) and NIH/NIA (R01 AG056648).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Srinivasan, S. Early exposure to a systemic stressor confers protection later in life. Nat Aging 4, 10–11 (2024). https://doi.org/10.1038/s43587-023-00553-4
Published:
Issue Date:
DOI: https://doi.org/10.1038/s43587-023-00553-4