In vivo reprogramming by expression of the transcription factors OCT4, SOX2, KLF4, and MYC (OSKM factors) has been associated with early mortality and cancer. We report that these adverse effects are associated with liver and intestinal dysfunction. Strategic control of OSKM expression in these organs through a newly developed transgenic mouse model reduced adverse effects. Our model yields valuable insights into the potential of in vivo reprogramming for rejuvenation and regeneration.
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References
Ocampo, A. et al. In vivo amelioration of age-associated hallmarks by partial reprogramming. Cell 167, 1719–1733.e12 (2016). This paper reports lifespan extension in a mouse model of premature aging, and enhancement of the regenerative capacity of aged tissues by partial reprogramming.
Browder, K. C. et al. In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice. Nat. Aging 2, 243–253 (2022). This paper reports reversal molecular markers of aging by partial reprogramming.
Chen, Y. et al. Reversible reprogramming of cardiomyocytes to a fetal state drives heart regeneration in mice. Science 373, 1537–1540 (2021). This work shows an improvement in heart regeneration by the induction of partial reprogramming.
Lu, Y. et al. Reprogramming to recover youthful epigenetic information and restore vision. Nature 588, 124–129 (2020). This paper shows that partial reprogramming with OSK stimulates axon regrowth following injury and effectively restores lost vision in both a mouse model of glaucoma and in elderly mice.
Abad, M. et al. Reprogramming in vivo produces teratomas and iPS cells with totipotency features. Nature 502, 340–345 (2013). This report is a seminal work that showed the consequences of in vivo reprogramming.
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This is a summary of: Parras, A. et al. In vivo reprogramming leads to premature death linked to hepatic and intestinal failure. Nat. Aging https://doi.org/10.1038/s43587-023-00528-5 (2023).
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In vivo reprogramming that spares the liver and intestine shows reduced toxicity in mice. Nat Aging 3, 1484–1485 (2023). https://doi.org/10.1038/s43587-023-00533-8
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DOI: https://doi.org/10.1038/s43587-023-00533-8
