Plants have an additional organelle to animals (the chloroplast), which means that they have a greater repertoire of protein homeostasis (proteostasis) mechanisms. We find that chloroplast proteostasis components prevent aggregation of a pathogenic fragment of human huntingtin expressed in plants, which reveals a potential avenue for therapeutic intervention in human proteinopathies.
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This is a summary of: Llamas, E. et al. In planta expression of human polyQ-expanded huntingtin fragment reveals mechanisms to prevent disease-related protein aggregation. Nat. Plants, https://doi.org/10.1038/s43587-023-00502-1 (2023).
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A chloroplast proteostasis factor prevents aggregation of a human disease-related protein. Nat Aging 3, 1323–1324 (2023). https://doi.org/10.1038/s43587-023-00503-0
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DOI: https://doi.org/10.1038/s43587-023-00503-0
