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Metabolic aging

It is a branched road to adipose tissue aging

Nature Aging volume 3, pages 911–912 (2023)Cite this article

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Han et al. provide a substantial contribution to our limited comprehension of the mechanisms of aging in adipose tissue. They show that, with age, increased levels of adipose CRTC2 decrease the breakdown of branched-chain amino acids and activate mTORC1. This in turn leads to increased levels of senescence-associated secretory phenotype factors, which promotes senescence and adipose dysfunction.

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Fig. 1: Proposed mechanism for the role of CRTC2 in adipose aging.

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Acknowledgements

We thank the members of the laboratory of H.Y.C. for their helpful comments on the manuscript. The authors are supported by the Israel Science Foundation (777/16 and 890/21), The US-Israel Binational Science Foundation (2019312) and the SAGOL center of healthy human aging.

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  1. The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel

    N. Touitou, B. Lerrer & H. Y. Cohen

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  1. N. Touitou
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  2. B. Lerrer
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  3. H. Y. Cohen
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Correspondence to H. Y. Cohen.

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Touitou, N., Lerrer, B. & Cohen, H.Y. It is a branched road to adipose tissue aging. Nat Aging 3, 911–912 (2023). https://doi.org/10.1038/s43587-023-00456-4

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