We found evolutionarily conserved astrocyte and microglia subpopulations shared across multiple brain regions. We reveal similarities and differences between Alzheimer’s disease glia and Parkinson’s disease glia, as well as regional variance linked to disease pathology and neurodegeneration.
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This is a summary of: Xu, J. et al. Human striatal glia differentially contribute to AD- and PD-specific neurodegeneration. Nat. Aging https://doi.org/10.1038/s43587-023-00363-8 (2023).
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Shared and disease-specific glial gene expression changes in neurodegenerative diseases. Nat Aging 3, 246–247 (2023). https://doi.org/10.1038/s43587-023-00378-1
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DOI: https://doi.org/10.1038/s43587-023-00378-1
