Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Sex and gender considerations in dementia: a call for global research

Studies have identified sex and/or gender differences in Alzheimer’s disease, but few have examined other dementias. We highlight sex and gender differences in other dementias, discuss sociocultural factors and provide a framework for future global studies.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it

$39.95

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Proposed framework to investigate sex and gender differences in AD and non-AD dementias globally.

References

  1. Mielke, M. M. et al. Alzheimers Dement. 18, 2707–2724 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Udeh-Momoh, C. & Watermeyer, T. Ageing Res. Rev. 71, 101459 (2021).

    Article  CAS  PubMed  Google Scholar 

  3. Kane, J. P. M. et al. Alzheimers Res. Ther. 10, 19 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Jurado-Coronel, J. C. et al. Front. Neuroendocrinol. 50, 18–30 (2018).

    Article  CAS  PubMed  Google Scholar 

  5. Pengo, M. et al. Neurol. Sci. 43, 5281–5287 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Illán‐Gala, I. et al. Alzheimers Dement. 17, 1329–1341 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Curtis, A. F. et al. Neurology 89, 1633–1642 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  8. de Boer, S. C. M. et al. J. Alzheimers Dis. 84, 1153–1161 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Gannon, O., Robison, L., Custozzo, A. & Zuloaga, K. Neurochem. Internatl 127, 38–55 (2018).

    Article  Google Scholar 

  10. Huo, N. et al. Neurology 98, e623–e632 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  11. Mayeda, E. R. Am. J. Epidemiol. 188, 1224–1227 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  12. Barnes, L. L., Lamar, M. & Schneider, J. A. Brain Res. 1719, 11–16 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Liesinger, A. M. et al. Acta Neuropathol. 136, 873–885 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  14. Subramaniapillai, S. et al. Front. Neuroendocrinol. 60, 100879 (2021).

    Article  PubMed  Google Scholar 

  15. Huque, H. et al. J. Alzheimers Dis. https://doi.org/10.3233/JAD-220724 (2022).

    Article  Google Scholar 

Download references

Acknowledgements

C.V.-C. receives funding from the National Institute on Aging (NIA) K99AG073452. M.M.M. receives funding from the National Institute on Aging (RF1 AG055151, U54 AG044170, RF1 AG077386; RF1 AG079397). C.U.-M. is funded by Janssen R&D, Gates Ventures, Takeda and Merck, and received project grants from the RoseTrees Foundation Trust, Alzheimer Research UK and the British Society for Neuroendocrinology.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Michelle M. Mielke.

Ethics declarations

Competing interests

M.M.M. has served on scientific advisory boards and/or has consulted for Biogen, LabCorp, Lilly, Merck, PeerView Institute, Siemens Healthineers, and Sunbird Bio unrelated to the current manuscript. The other authors declare no competing interests.

Peer review

Peer review information

Nature Aging thanks Maria Carmela Tartaglia and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Vila-Castelar, C., Udeh-Momoh, C., Aggarwal, N.T. et al. Sex and gender considerations in dementia: a call for global research. Nat Aging 3, 463–465 (2023). https://doi.org/10.1038/s43587-023-00374-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s43587-023-00374-5

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing