Studies have identified sex and/or gender differences in Alzheimer’s disease, but few have examined other dementias. We highlight sex and gender differences in other dementias, discuss sociocultural factors and provide a framework for future global studies.
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Mielke, M. M. et al. Alzheimers Dement. 18, 2707–2724 (2022).
Udeh-Momoh, C. & Watermeyer, T. Ageing Res. Rev. 71, 101459 (2021).
Kane, J. P. M. et al. Alzheimers Res. Ther. 10, 19 (2018).
Jurado-Coronel, J. C. et al. Front. Neuroendocrinol. 50, 18–30 (2018).
Pengo, M. et al. Neurol. Sci. 43, 5281–5287 (2022).
Illán‐Gala, I. et al. Alzheimers Dement. 17, 1329–1341 (2021).
Curtis, A. F. et al. Neurology 89, 1633–1642 (2017).
de Boer, S. C. M. et al. J. Alzheimers Dis. 84, 1153–1161 (2021).
Gannon, O., Robison, L., Custozzo, A. & Zuloaga, K. Neurochem. Internatl 127, 38–55 (2018).
Huo, N. et al. Neurology 98, e623–e632 (2022).
Mayeda, E. R. Am. J. Epidemiol. 188, 1224–1227 (2019).
Barnes, L. L., Lamar, M. & Schneider, J. A. Brain Res. 1719, 11–16 (2019).
Liesinger, A. M. et al. Acta Neuropathol. 136, 873–885 (2018).
Subramaniapillai, S. et al. Front. Neuroendocrinol. 60, 100879 (2021).
Huque, H. et al. J. Alzheimers Dis. https://doi.org/10.3233/JAD-220724 (2022).
C.V.-C. receives funding from the National Institute on Aging (NIA) K99AG073452. M.M.M. receives funding from the National Institute on Aging (RF1 AG055151, U54 AG044170, RF1 AG077386; RF1 AG079397). C.U.-M. is funded by Janssen R&D, Gates Ventures, Takeda and Merck, and received project grants from the RoseTrees Foundation Trust, Alzheimer Research UK and the British Society for Neuroendocrinology.
M.M.M. has served on scientific advisory boards and/or has consulted for Biogen, LabCorp, Lilly, Merck, PeerView Institute, Siemens Healthineers, and Sunbird Bio unrelated to the current manuscript. The other authors declare no competing interests.
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Nature Aging thanks Maria Carmela Tartaglia and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.
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Vila-Castelar, C., Udeh-Momoh, C., Aggarwal, N.T. et al. Sex and gender considerations in dementia: a call for global research. Nat Aging 3, 463–465 (2023). https://doi.org/10.1038/s43587-023-00374-5