Wang Lin and his colleagues explore how aging reprograms spatially unique pathways in liver endothelial cells to cause fibrosis. They find that loss of KIT in liver endothelial cells close to the central vein upregulates the chemokine receptor CXCR4 to stimulate inflammation, enhance fibrosis and increase lipid accumulation in aged liver.
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We are grateful to Y. Ren and X. Huang for their helpful discussion and input. The authors are supported by National Natural Science Foundation of China (82125002, 81925005, 92268201, U21A20333).
The authors declare no competing interests.
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Cao, Z., Ding, BS. Aging breaks liver vascular ‘zone defense’. Nat Aging 3, 242–243 (2023). https://doi.org/10.1038/s43587-023-00371-8