Zhang and colleagues demonstrate how the premature aging phenotypes in progeria involve a mitotic spindle-assembly-checkpoint protein, BUBR1. BUBR1 is misanchored to the nuclear membrane by progerin and its mRNA is destabilized in progeria, preventing it from functioning properly.
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Acknowledgements
The authors are supported by NIH/NHLBI R01HL138252 (K.C.) and a seed grant from Brain and Behaviour Institute (BBI) at the University of Maryland College Park (H.X.).
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Xue, H., Cao, K. Missing checkpoints in premature aging. Nat Aging 3, 146–147 (2023). https://doi.org/10.1038/s43587-022-00351-4
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DOI: https://doi.org/10.1038/s43587-022-00351-4