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Atherosclerosis

Old bones control smooth muscle clones

Nature Aging volume 3, pages 9–10 (2023)Cite this article

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Aging is known to exacerbate atherosclerosis, but the mechanisms have been largely unknown. A study in Nature Aging reveals a bone-marrow-controlled axis of clonality during atherosclerosis, showing that aged bones drive an inflammatory milieu that promotes smooth muscle polyclonality and the formation of larger lesions.

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Fig. 1: Bone-marrow-derived cells from aged mice induce SMC polyclonality and augmented lesion size.

References

  1. Tsao, C. W. et al. Circulation 145, e153–e639 (2022).

    Article  Google Scholar 

  2. Wang, J. C. & Bennett, M. Circ. Res. 111, 245–259 (2012).

    Article  CAS  Google Scholar 

  3. Kabir, I. et al. Nat. Aging https://doi.org/10.1038/s43587-022-00342-5 (2023).

    Article  Google Scholar 

  4. Greaves, M. & Maley, C. C. Nature 481, 306–313 (2012).

    Article  CAS  Google Scholar 

  5. Nowell, P. C. Science 194, 23–28 (1976).

    Article  CAS  Google Scholar 

  6. Fuster, J. J. et al. Science 355, 842–847 (2017).

    Article  CAS  Google Scholar 

  7. Schwartz, S. M., Virmani, R. & Majesky, M. W. F1000 Res. 7, 1969 (2018).

    Article  CAS  Google Scholar 

  8. Benditt, E. P. Circulation 50, 650–652 (1974).

    Article  CAS  Google Scholar 

  9. Chung, I. M., Schwartz, S. M. & Murry, C. E. Am. J. Pathol. 152, 913–923 (1998).

    CAS  Google Scholar 

  10. Thomas, W. A., Florentin, R. A., Reiner, J. M., Lee, W. M. & Lee, K. T. Exp. Mol. Pathol. 24, 244–260 (1976).

    Article  CAS  Google Scholar 

  11. Rinkevich, Y., Lindau, P., Ueno, H., Longaker, M. T. & Weissman, I. L. Nature 476, 409–413 (2011).

    Article  CAS  Google Scholar 

  12. Misra, A. et al. Nat. Commun. 9, 2073 (2018).

    Article  Google Scholar 

  13. Newman, A. A. C. et al. JCI Insight 3, e121017 (2018).

    Article  Google Scholar 

Download references

Acknowledgements

G.K.O. was supported in part by NIH R01 HL155165 and R01 HL156849 to G.K.O. V.S. was supported by Basic and Translational Cardiovascular Training Grant NIH T32 HL007284 and NRSA Postdoctoral Fellowship NIH F32 HL156491.

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Authors and Affiliations

  1. Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, USA

    Vlad Serbulea, Rebecca A. Deaton & Gary K. Owens

  2. Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA

    Gary K. Owens

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  1. Vlad Serbulea
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  2. Rebecca A. Deaton
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  3. Gary K. Owens
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Correspondence to Gary K. Owens.

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Serbulea, V., Deaton, R.A. & Owens, G.K. Old bones control smooth muscle clones. Nat Aging 3, 9–10 (2023). https://doi.org/10.1038/s43587-022-00346-1

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