We found that aging is accompanied by a reduction in cardiomyocyte nuclear size and increased stiffness, dependent on loss of A-type lamins. Mechanistically, age-dependent nuclear remodeling represses expression of cardiogenic transcription factors that are required for heart contractility. Preserving lamin or transcription factors delays cardiac decline.
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This is a summary of: Kirkland, N. J. et al. Age-dependent Lamin changes induce cardiac dysfunction via dysregulation of cardiac transcriptional programs. Nat. Aging, https://doi.org/10.1038/s43587-022-00323-8 (2022).
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Nuclear remodeling drives age-related cardiac dysfunction. Nat Aging 3, 15–16 (2023). https://doi.org/10.1038/s43587-022-00324-7
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DOI: https://doi.org/10.1038/s43587-022-00324-7
