In our aging global population and with no effective treatments, the cognitive impairments associated with Alzheimer’s disease represent a major healthcare problem. A recent study in Nature Aging highlights intermittent fasting as a potential way to decrease the progression of Alzheimer’s disease in mice through changes to the gut microbiota.
This is a preview of subscription content, access via your institution
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 per month
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Livingston, G. et al. Lancet 396, 413–446 (2020).
Long, J. M. & Holtzman, D. M. Cell 179, 312–339 (2019).
Connell, E. et al. Mol. Neurodegener. 17, 43 (2022).
Pan, R.-Y. et al. Nat. Aging, https://doi.org/10.1038/s43587-022-00311-y (2022).
Braak, H., Braak, E. & Bohl, J. Eur. Neurol. 33, 403–408 (1993).
Bercik, P. et al. Gastroenterology 141, 599–609 (2011).
Kowalski, K. & Mulak, A. J. Neurogastroenterol. Motil. 25, 48–60 (2019).
Kim, N. et al. Brain Behav. Immun. 98, 357–365 (2021).
Mattson, M. P., Moehl, K., Ghena, N., Schmaedick, M. & Cheng, A. Nat. Rev. Neurosci. 19, 81–94 (2018).
Liu, Z. et al. Nat. Commun. 11, 855 (2020).
Oakley, H. et al. J. Neurosci. 26, 10129–10140 (2006).
Vogt, N. M. et al. Sci. Rep. 7, 13537 (2017).
Horgusluoglu, E. et al. Alzheimers Dement. 18, 1260–1278 (2022).
Price, J. L. & Morris, J. C. Ann. Neurol. 45, 358–368 (1999).
Berron, D. et al. J. Neurosci. 39, 8788–8797 (2019).
The authors receive funding from Science Foundation Ireland (SFI) under grant number SFI/FFP/6820. Y.M.N. is funded Investigator of the APC Microbiome Ireland.
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Nicolas, S., Nolan, Y.M. Intermittent fasting to slow down Alzheimer’s disease. Nat Aging 2, 982–983 (2022). https://doi.org/10.1038/s43587-022-00320-x