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Imaging Alzheimer’s pathology stage by stage

Tau neuropathology is a defining feature of Alzheimer’s disease. For decades, its progression throughout the cortex has been captured post mortem using Braak stages. A new study replicated Braak staging in living patients using positron emission tomography, showing associations with other biomarkers and clinical deficits.

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Fig. 1: Tau-PET-based Braak staging, showing relationships with fluid biomarkers and cognitive impairment.


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The authors are supported by Race Against Dementia Alzheimer’s Research UK (ARUK-RADF2021A-010 to M.M.) and the National Institute on Aging (K99AG065501 to R.L.J.).

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Correspondence to Renaud La Joie.

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The authors declare no competing interests.

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Malpetti, M., La Joie, R. Imaging Alzheimer’s pathology stage by stage. Nat Aging 2, 465–467 (2022).

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