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ALZHEIMER’S DISEASE

Imaging Alzheimer’s pathology stage by stage

Nature Aging volume 2, pages 465–467 (2022)Cite this article

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Tau neuropathology is a defining feature of Alzheimer’s disease. For decades, its progression throughout the cortex has been captured post mortem using Braak stages. A new study replicated Braak staging in living patients using positron emission tomography, showing associations with other biomarkers and clinical deficits.

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Fig. 1: Tau-PET-based Braak staging, showing relationships with fluid biomarkers and cognitive impairment.

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Acknowledgements

The authors are supported by Race Against Dementia Alzheimer’s Research UK (ARUK-RADF2021A-010 to M.M.) and the National Institute on Aging (K99AG065501 to R.L.J.).

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Authors and Affiliations

  1. Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA

    Maura Malpetti & Renaud La Joie

  2. Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK

    Maura Malpetti

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  1. Maura Malpetti
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  2. Renaud La Joie
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Correspondence to Renaud La Joie.

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The authors declare no competing interests.

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Malpetti, M., La Joie, R. Imaging Alzheimer’s pathology stage by stage. Nat Aging 2, 465–467 (2022). https://doi.org/10.1038/s43587-022-00236-6

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