Aging is accompanied by a gradual decline of cell proliferation potential. FOXM1 is a transcription factor involved in cellular proliferation and cell cycle progression. Ribeiro et al. show that cyclic expression of a truncated form of a FOXM1 transgene in vivo can delay senescence-associated progeroid and natural aging phenotypes in mice.
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References
Kalathil, D., John, S. & Nair, A. S. Front. Oncol. 10, 626836 (2021).
Laoukili, J., Stahl, M. & Medema, R. H. Biochim. Biophys. Acta 1775, 92–102 (2007).
Macedo, J. C. et al. Nat. Commun. 9, 2834 (2018).
Ribeiro, R. et al. Nat. Aging, https://doi.org/10.1038/s43587-022-00209-9 (2022).
Ly, D. H., Lockhart, D. J., Lerner, R. A. & Schultz, P. G. Science 287, 2486–2492 (2000).
Osorio, F. G. et al. Sci. Transl. Med. 3, 106ra107 (2011).
Gartel, A. L. Cancer Res. 77, 3135–3139 (2017).
Colman, R. J. et al. Science 325, 201–204 (2009).
Xu, M. et al. Nat. Med. 24, 1246–1256 (2018).
Ocampo, A. et al. Cell 167, 1719–1733 (2016).
Golson, M. L. et al. Diabetes 64, 3829–3838 (2015).
Kondo, T. et al. Cancer Res. 80, 471–483 (2020).
Cheng, Y. Y. et al. EMBO Mol. Med. 9, 251–264 (2017).
Xie, Z. et al. Nucleic Acids Res. 38, 8027–8038 (2010).
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Ouchi, Y., Sahu, S.K. & Izpisua Belmonte, J.C. FOXM1 delays senescence and extends lifespan. Nat Aging 2, 373–374 (2022). https://doi.org/10.1038/s43587-022-00222-y
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DOI: https://doi.org/10.1038/s43587-022-00222-y