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Structural changes in cerebrospinal fluid proteins are associated with brain aging

Nature Aging volume 2, pages 375–376 (2022)Cite this article

An Author Correction to this article was published on 21 June 2022

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Mass spectrometry analysis of mouse cerebrospinal fluid revealed that several proteins change in abundance or structure during aging. The six proteins that show the most robust structural changes are associated with cognition or Alzheimer’s disease in human cerebrospinal fluid, thus revealing candidate diagnostic biomarkers and potential therapeutic targets.

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Fig. 1: CSF proteins change with aging and AD.

Change history

References

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This is a summary of: Shuken, S. R. et al. Limited proteolysis–mass spectrometry reveals aging-associated changes in cerebrospinal fluid protein abundances and structures. Nat. Aging https://doi.org/10.1038/s43587-022-00196-x (2022)

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Structural changes in cerebrospinal fluid proteins are associated with brain aging. Nat Aging 2, 375–376 (2022). https://doi.org/10.1038/s43587-022-00213-z

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