In cohorts of young and older adults who were comprehensively phenotyped, Janssens and colleagues traverse an important translational gap by providing compelling evidence for the purported link between elevated NAD+ levels and the healthy aging muscle phenotype in humans.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
He, W., Goodkind, D. & Kowal, P. An Aging World: 2015. U.S. Census Bureau International Population Reports, P95/16-1 (U.S. Government Publishing Office, 2016).
Atella, V. et al. Aging Cell 18, e12861 (2019).
Seals, D. R., Justice, J. N. & LaRocca, T. J. J. Physiol. 594, 2001–2024 (2016).
Janssens, G. E. et al. Nat. Aging https://doi.org/10.1038/s43587-022-00174-3 (2022).
Yoshino, J., Baur, J. A. & Imai, S. I. Cell Metab. 27, 513–528 (2018).
Tarragó, M. G. et al. Cell Metab. 27, 1081–1095 (2018).
Gardell, S. J. et al. Nat. Commun. 10, 3241 (2019).
Migliavacca, E. et al. Nat. Commun. 10, 5808 (2019).
Yoshino, M. et al. Science 372, 1224–1229 (2021).
Remie, C. M. E. et al. Am. J. Clin. Nutr. 112, 413–426 (2020).
Dollerup, O. L. et al. Am. J. Clin. Nutr. 108, 343–353 (2018).
Dollerup, O. L. et al. J. Physiol. 598, 731–754 (2020).
Liu, L. et al. Cell Metab. 27, 1067–1080 (2018).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Gardell, S.J., Coen, P.M. NAD+ and human muscle health. Nat Aging 2, 195–196 (2022). https://doi.org/10.1038/s43587-022-00192-1
Published:
Issue Date:
DOI: https://doi.org/10.1038/s43587-022-00192-1