Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

HUMAN AGING

NAD+ and human muscle health

In cohorts of young and older adults who were comprehensively phenotyped, Janssens and colleagues traverse an important translational gap by providing compelling evidence for the purported link between elevated NAD+ levels and the healthy aging muscle phenotype in humans.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: NAD+ metabolism in human skeletal muscle.

References

  1. He, W., Goodkind, D. & Kowal, P. An Aging World: 2015. U.S. Census Bureau International Population Reports, P95/16-1 (U.S. Government Publishing Office, 2016).

  2. Atella, V. et al. Aging Cell 18, e12861 (2019).

    Article  CAS  Google Scholar 

  3. Seals, D. R., Justice, J. N. & LaRocca, T. J. J. Physiol. 594, 2001–2024 (2016).

    Article  CAS  Google Scholar 

  4. Janssens, G. E. et al. Nat. Aging https://doi.org/10.1038/s43587-022-00174-3 (2022).

    Article  Google Scholar 

  5. Yoshino, J., Baur, J. A. & Imai, S. I. Cell Metab. 27, 513–528 (2018).

    Article  CAS  Google Scholar 

  6. Tarragó, M. G. et al. Cell Metab. 27, 1081–1095 (2018).

    Article  Google Scholar 

  7. Gardell, S. J. et al. Nat. Commun. 10, 3241 (2019).

    Article  Google Scholar 

  8. Migliavacca, E. et al. Nat. Commun. 10, 5808 (2019).

    Article  CAS  Google Scholar 

  9. Yoshino, M. et al. Science 372, 1224–1229 (2021).

    Article  CAS  Google Scholar 

  10. Remie, C. M. E. et al. Am. J. Clin. Nutr. 112, 413–426 (2020).

    Article  Google Scholar 

  11. Dollerup, O. L. et al. Am. J. Clin. Nutr. 108, 343–353 (2018).

    Article  Google Scholar 

  12. Dollerup, O. L. et al. J. Physiol. 598, 731–754 (2020).

    Article  CAS  Google Scholar 

  13. Liu, L. et al. Cell Metab. 27, 1067–1080 (2018).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Paul M. Coen.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gardell, S.J., Coen, P.M. NAD+ and human muscle health. Nat Aging 2, 195–196 (2022). https://doi.org/10.1038/s43587-022-00192-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s43587-022-00192-1

Search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research