Vascular senescence has been implicated in atherosclerosis. By characterizing SNPs in the p16-encoding CDKN2A/B locus, a new study in Nature Aging identifies CUX1 as a binding protein of an atherosclerosis-associated functional SNP, which activates CDKN2A expression and senescence in endothelial cells, thus providing a mechanism of transcriptional senescence regulation.
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The authors declare no competing interests.
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Chan, A.S.L., Narita, M. A role for CUX1 in the regulation of p16 and senescence. Nat Aging 2, 100–101 (2022). https://doi.org/10.1038/s43587-022-00173-4