The ability to remain true to cellular identity and function is lost during aging and carcinogenesis when DNA damage triggers inflammation that progressively erodes homeostatic cues. Shalabi et al. show that these losses are accelerated in patients with germline cancer mutations in DNA repair genes and are independent of chronological age.
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Acknowledgements
This work was supported by National Cancer Institute 1 R35 CA 197694 and Cancer Research UK C19767/A27145 awards to T.D.T.
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Caruso, J.A., Tlsty, T.D. Remaining true to one’s identity. Nat Aging 1, 757–759 (2021). https://doi.org/10.1038/s43587-021-00113-8
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DOI: https://doi.org/10.1038/s43587-021-00113-8