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INFLAMMAGING

An inflammatory clock for healthy aging

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Inflammation is known to be elevated with progressive age. In this issue, Sayed et al. identify a group of circulating cytokines that correlate with health decline in aging, particularly the chemokine CXCL9. The findings offer a new understanding of how wellbeing and biological resilience are independent from chronological age.

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Fig. 1: iAge offers an evaluation of overall health status independent of chronological age.

References

  1. Sayed, N. et al. Nat. Aging https://doi.org/10.1038/s43587-021-00082-y (2021).

  2. Ferrucci, L. et al. Blood 115, 3810–3816 (2010).

    Article  CAS  Google Scholar 

  3. Fulop, T. et al. Front. Immunol. 8, 1960 (2017).

    Article  Google Scholar 

  4. Franceschi, C. et al. Ann. NY Acad. Sci. 908, 244–254 (2000).

    Article  CAS  Google Scholar 

  5. Cohen, H. J., Pieper, C. F., Harris, T., Rao, K. M. & Currie, M. S. J. Gerontol. A Biol. Sci. Med. Sci. 52, M201–M208 (1997).

    Article  CAS  Google Scholar 

  6. Newman, A. B. et al. Int. J. Epidemiol. 45, 1135–1145 (2016).

    Article  Google Scholar 

  7. Gorelick, P. B. Ann. NY Acad. Sci. 1207, 155–162 (2010).

    Article  Google Scholar 

  8. Fabbri, E. et al. J. Gerontol. A Biol. Sci. Med. Sci. 70, 63–70 (2015).

    Article  CAS  Google Scholar 

  9. Schaap, L. A. et al. J. Gerontol. A Biol. Sci. Med. Sci. 64, 1183–1189 (2009).

    Article  Google Scholar 

  10. Zhang, Y. et al. Front. Oncol. 10, 1049 (2020).

    Article  Google Scholar 

  11. Gao, H. F. et al. Aging (Albany NY) 12, 502–517 (2020).

    Article  CAS  Google Scholar 

  12. Park, M. K. et al. J. Immunol. 169, 1433–1443 (2002).

    Article  CAS  Google Scholar 

  13. Castro-Diehl, C. et al. PLoS ONE 16, e0251308 (2021).

    Article  CAS  Google Scholar 

  14. Rojas-Vázquez, S., Blasco-Chamarro, L., López-Fabuel, I., Martínez-Máñez, R. & Fariñas, I. Front. Neurosci. 15, 666881 (2021).

    Article  Google Scholar 

  15. Amarasekera, A. T., Chang, D., Schwarz, P. & Tan, T. C. Age Ageing 50, 725–732 (2021).

    Article  Google Scholar 

Download references

Acknowledgements

M.L.I.-A. is supported by the National Institutes of Health (R35HL140014).

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Correspondence to M. Luisa Iruela-Arispe.

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The author declares no competing interests.

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Iruela-Arispe, M.L. An inflammatory clock for healthy aging. Nat Aging 1, 574–575 (2021). https://doi.org/10.1038/s43587-021-00085-9

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