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Epigenetic codes of mitochondrial homeostasis

Mitochondrial dysfunction can result in numerous diseases, including neurodegenerative disorders. CBP/p300, a histone acetyltransferase, has been uncovered as a key factor in the response to mitochondrial perturbation. It controls transcription of mitochondrial stress response genes, promotes innate immunity and enhances longevity.

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Fig. 1: CBP-1 mediates UPRmt activation and elicits beneficial effects upon mild mitochondrial perturbation.


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Correspondence to Ying Liu.

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Liu, Y. Epigenetic codes of mitochondrial homeostasis. Nat Aging 1, 153–154 (2021).

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