Mitochondrial dysfunction can result in numerous diseases, including neurodegenerative disorders. CBP/p300, a histone acetyltransferase, has been uncovered as a key factor in the response to mitochondrial perturbation. It controls transcription of mitochondrial stress response genes, promotes innate immunity and enhances longevity.
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Liu, Y. Epigenetic codes of mitochondrial homeostasis. Nat Aging 1, 153–154 (2021). https://doi.org/10.1038/s43587-021-00034-6
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