The pre-metastatic niche is a complex microenvironment formed by the influence of tumor-derived factors on stromal and immune cells at distant sites of disseminated tumor-cell colonization. Signaling through the kinase p38α and regulation of the type I interferon receptor are now linked to formation of the pre-metastatic niche.
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Kaczanowska, S., Kaplan, R.N. Mapping the switch that drives the pre-metastatic niche. Nat Cancer 1, 577–579 (2020). https://doi.org/10.1038/s43018-020-0076-9