We demonstrated increased phospholipid peroxidation due to the formation of monolysocardiolipin–cytochrome c complexes in tafazzin-deficient models of Barth syndrome. We found that a specific anti-peroxidase agent inhibited this complex and improved mitochondrial respiration. Thus, targeting the deleterious peroxidase activity offers a potential therapeutic approach to treat Barth syndrome.
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References
Barth, P. G. et al. An X-linked mitochondrial disease affecting cardiac muscle, skeletal muscle and neutrophil leucocytes. J. Neurol. Sci. 62, 327–355 (1983). This is the first report of the disorder now known as BTHS.
Vreken, P. et al. Defective remodeling of cardiolipin and phosphatidylglycerol in Barth syndrome. Biochem. Biophys. Res. Commun. 279, 378–382 (2000). This paper identifies CL remodelling as the defect in BTHS.
Kagan, V. E. et al. Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors. Nat. Chem. Biol. 1, 223–232 (2005). This paper shows formation of CL–cyt c complexes with peroxidase activity.
Claypool, S. M., McCaffery, J. M. & Koehler, C. M. Mitochondrial mislocalization and altered assembly of a cluster of Barth syndrome mutant tafazzins. J. Cell Biol. 174, 379–390 (2006). This paper shows that tafazzin is localized in the intermembrane space-facing leaflets of mitochondrial membranes.
Atkinson, J. et al. A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death. Nat. Commun. 2, 497 (2011). This paper describes the design and synthesis of mitochondria-targeted imidazole-substituted fatty acids.
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This is a summary of: Kagan, V. E. et al. Anomalous peroxidase activity of cytochrome c is the primary pathogenic target in Barth syndrome. Nat. Metab. https://doi.org/10.1038/s42255-023-00926-4 (2023).
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A monolysocardiolipin–cytochrome c peroxidase causes defects in Barth syndrome. Nat Metab 5, 2043–2044 (2023). https://doi.org/10.1038/s42255-023-00925-5
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DOI: https://doi.org/10.1038/s42255-023-00925-5
