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Adipose tissue

Fuelling the fire: de novo lipogenesis primes thermogenesis

Nature Metabolism volume 5, pages 1646–1648 (2023)Cite this article

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Brown adipose tissue has a crucial role in regulating body temperature in mammals. Recent research delves into the notion of thermogenic memory and identifies a subset of adipocytes that enhance the response to repeated stimulation events via de novo lipogenesis.

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Fig. 1: DNL and the production of acylcarnitines prime brown adipocytes for an enhanced thermogenic response.

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Acknowledgements

The work of the authors is supported by an ERC Senior Investigator award (669879) and a BBSRC grant (BB/X001237/1). S.R.-F.’s work is also supported by a Sir Henry Wellcome postdoctoral fellowship (222748/Z/21/Z). A.V.-P.’s research is supported by MRC and BHF.

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Authors and Affiliations

  1. Wellcome–MRC Institute of Metabolic Science and Medical Research Council Metabolic Diseases Unit, University of Cambridge, Cambridge, UK

    S. Rodríguez-Fdez & A. Vidal-Puig

  2. Victor Phillip Dahdaleh Heart & Lung Research Institute, Cambridge, UK

    S. Rodríguez-Fdez & A. Vidal-Puig

  3. Cambridge University Nanjing Centre of Technology and Innovation, Nanjing, P.R. of China

    A. Vidal-Puig

  4. Centro de Investigacion Principe Felipe (CIPF), Valencia, Spain

    A. Vidal-Puig

Authors
  1. S. Rodríguez-Fdez
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  2. A. Vidal-Puig
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Correspondence to A. Vidal-Puig.

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The authors declare no competing interests.

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Rodríguez-Fdez, S., Vidal-Puig, A. Fuelling the fire: de novo lipogenesis primes thermogenesis. Nat Metab 5, 1646–1648 (2023). https://doi.org/10.1038/s42255-023-00865-0

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