This study reveals that oxidative aneuploid cancer cells exhibit an upsurge of NADPH levels during mitosis, which neutralizes excessive reactive oxygen species and protects against chromosome mis-segregation.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Zou, Y. et al. Analysis of redox landscapes and dynamics in living cells and in vivo using genetically encoded fluorescent sensors. Nat. Protoc. 13, 2362–2386 (2018). This protocol introduces the use of iNap1 and presents the dynamic of redox metabolites in the cell cycle.
Patterson, J. C. et al. ROS and oxidative stress are elevated in mitosis during asynchronous cell cycle progression and are exacerbated by mitotic arrest. Cell Syst. 8, 163–167.e162 (2019). This paper reports that ROS are elevated in G2/M phase and are exacerbated by mitotic arrest.
Icard, P. & Simula, L. Metabolic oscillations during cell-cycle progression. Trends Endocrinol. Metab. 33, 447–450 (2022). A review that presents metabolic oscillations in cell cycle progression.
Hayes, J. D. et al. Oxidative stress in cancer. Cancer Cell 38, 167–197 (2020). A review that presents the role of NADPH in countering oxidative stress and maintaining intracellular redox homeostasis.
Zhu, J. et al. Cellular stress associated with aneuploidy. Dev. Cell 44, 420–431 (2018). A review that presents that oxidative stress and mitotic stress are associated with aneuploidy.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Cheng, A. et al. A mitotic NADPH upsurge promotes chromosome segregation and tumour progression in aneuploid cancer cells. Nat. Metab., https://doi.org/10.1038/s42255-023-00832-9 (2023).
Rights and permissions
About this article
Cite this article
NADPH increase in mitosis in aneuploid tumour cells protects against genomic aberrations. Nat Metab 5, 1086–1087 (2023). https://doi.org/10.1038/s42255-023-00848-1
Published:
Issue Date:
DOI: https://doi.org/10.1038/s42255-023-00848-1
