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Cardiac metabolism

Bile acid binds heart failure and inflammation

Nature Metabolism volume 5, pages 1260–1261 (2023)Cite this article

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Mao et al. discover that heart failure-associated metabolic derangement results in cardiomyocyte cholesterol overload and accumulation of bile acid intermediates, which in turn trigger mitochondrial damage and inflammatory activation and thus promote heart failure.

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Fig. 1: Bile acids drive HF.

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Authors and Affiliations

  1. Division of Cardiology, UT Southwestern Medical Center, Dallas, TX, USA

    Dan Tong & Joseph A. Hill

  2. Harry S. Moss Heart Center, UT Southwestern Medical Center, Dallas, TX, USA

    Dan Tong & Joseph A. Hill

  3. Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX, USA

    Dan Tong & Joseph A. Hill

Authors
  1. Dan Tong
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  2. Joseph A. Hill
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Correspondence to Joseph A. Hill.

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The authors declare no competing interests.

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Tong, D., Hill, J.A. Bile acid binds heart failure and inflammation. Nat Metab 5, 1260–1261 (2023). https://doi.org/10.1038/s42255-023-00836-5

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