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Time-restricted feeding makes the mouse run like a pro

Time-restricted eating, a form of intermittent fasting, has shown promise in promoting metabolic health. In mice, limiting food accessibility only to the active cycle reduces body weight and improves glucose homeostasis; now, Xin et al. show that restricting feeding to the resting period increases their running performance.

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Fig. 1: Effects of time-restricted feeding on metabolic and physical fitness.

References

  1. Manoogian, E. N. C., Chow, L. S., Taub, P. R., Laferrère, B. & Panda, S. Endocr. Rev. 43, 405–436 (2022).

    Article  PubMed  Google Scholar 

  2. Hatori, M. et al. Cell Metab. 15, 848–860 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Kohsaka, A. et al. Cell Metab. 6, 414–421 (2007).

    Article  CAS  PubMed  Google Scholar 

  4. Manella, G. et al. Nat. Metab. 3, 829–842 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Arble, D. M., Bass, J., Laposky, A. D., Vitaterna, M. H. & Turek, F. W. Obesity 17, 2100–2102 (2009).

    Article  PubMed  Google Scholar 

  6. Xin, H. et al. Nat. Metab. https://doi.org/10.1038/s42255-023-00826-7 (2023).

    Article  PubMed  Google Scholar 

  7. Egan, B. & Zierath, J. R. Cell Metab. 17, 162–184 (2013).

    Article  CAS  PubMed  Google Scholar 

  8. Poole, D. C., Rossiter, H. B., Brooks, G. A. & Gladden, L. B. J. Physiol. 599, 737–767 (2021).

    Article  CAS  PubMed  Google Scholar 

  9. Mason, R. R. & Watt, M. J. Trends Endocrinol. Metab. 26, 144–152 (2015).

    Article  CAS  PubMed  Google Scholar 

Download references

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Correspondence to Chih-Hao Lee.

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Chalom, M.M., Lee, CH. Time-restricted feeding makes the mouse run like a pro. Nat Metab 5, 1082–1083 (2023). https://doi.org/10.1038/s42255-023-00833-8

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