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Liver disease

Writing and erasing ceramides to alter liver disease

Nature Metabolism volume 5, pages 727–729 (2023)Cite this article

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M6A RNA modifications mediate RNA processing and stability. Ceramides are lipid metabolites containing an amino acid-based backbone, which promote metabolic dysfunction. Wang et al. describe a novel m6A-dependent regulatory node that tunes ceramide-generating enzymes.

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Fig. 1: By altering the stability of mRNA transcripts, Mettl3–m6A alters sphingolipid metabolism.

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Acknowledgements

The authors received research support from the National Institutes of Health (DK115824, DK116888, and DK116450 to SAS; DK112826 and DK130296 to WLH), the American Diabetes Association (to WLH), the Margolis Foundation (to WLH).

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Authors and Affiliations

  1. Department of Nutrition and Integrative Physiology, University of Utah College of Health, Salt Lake City, UT, USA

    Mariah Weber-Stout, Scott A. Summers & William L. Holland

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  1. Mariah Weber-Stout
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  2. Scott A. Summers
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  3. William L. Holland
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Correspondence to William L. Holland.

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Competing interests

S.A.S. is a consultant, co-founder and shareholder in Centaurus Therapeutics, LLC. All other authors declare no competing interests.

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Weber-Stout, M., Summers, S.A. & Holland, W.L. Writing and erasing ceramides to alter liver disease. Nat Metab 5, 727–729 (2023). https://doi.org/10.1038/s42255-023-00809-8

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