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A new path for one-carbon conversion

Incorporating one-carbon molecules into metabolic engineering has involved altering central metabolism, which must overcome metabolic regulation. Developing one-carbon metabolic pathways that are orthogonal to central metabolism offers a promising alternative for bioproduct synthesis. Here, Chou, Lee, Zhu et al. describe an orthogonal pathway that has the potential for bioproduct synthesis from one-carbon molecules and can be independent of central metabolism.

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Fig. 1: The FORCE pathway for one-carbon conversion.


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S.W.S. is supported by Laboratory Directed Research and Development funding from Lawrence Berkeley National Laboratory.

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Correspondence to Steven W. Singer.

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Singer, S.W. A new path for one-carbon conversion. Nat Metab 3, 1286–1287 (2021).

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