Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

METABOLIC ENGINEERING

A new path for one-carbon conversion

Nature Metabolism volume 3, pages 1286–1287 (2021)Cite this article

Subjects

Incorporating one-carbon molecules into metabolic engineering has involved altering central metabolism, which must overcome metabolic regulation. Developing one-carbon metabolic pathways that are orthogonal to central metabolism offers a promising alternative for bioproduct synthesis. Here, Chou, Lee, Zhu et al. describe an orthogonal pathway that has the potential for bioproduct synthesis from one-carbon molecules and can be independent of central metabolism.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: The FORCE pathway for one-carbon conversion.

References

  1. Jiang, W. et al. Nat. Chem. Biol. 17, 845–855 (2021).

    Article  CAS  Google Scholar 

  2. Clomburg, J. M., Crumbley, A. M. & Gonzalez, R. Science 355, aag0804 (2017).

    Article  Google Scholar 

  3. Chou, A., Lee, S. H., Zhu, F., Clomburg, J. M. & Gonzalez, R. Nat. Metab. https://doi.org/10.1038/s42255-021-00453-0 (2021).

    Article  Google Scholar 

  4. Chou, A., Clomburg, J. M., Qian, S. & Gonzalez, R. Nat. Chem. Biol. 15, 900–906 (2019).

    Article  CAS  Google Scholar 

  5. Chen, F. Y.-H., Jung, H.-W., Tsuei, C.-Y. & Liao, J. C. Cell 182, 933–946.e14 (2020).

    Article  CAS  Google Scholar 

  6. Har, J. R. G., Agee, A., Bennett, R. K., Papoutsakis, E. T. & Antoniewicz, M. R. Appl. Microbiol. Biotechnol. 105, 869–876 (2021).

    Article  CAS  Google Scholar 

  7. Kim, S. et al. Nat. Chem. Biol. 16, 538–545 (2020).

    Article  CAS  Google Scholar 

  8. Sánchez-Andrea, I. et al. Nat. Commun. 11, 5090 (2020).

    Article  Google Scholar 

Download references

Acknowledgements

S.W.S. is supported by Laboratory Directed Research and Development funding from Lawrence Berkeley National Laboratory.

Author information

Authors and Affiliations

  1. Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA

    Steven W. Singer

Authors
  1. Steven W. Singer
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Steven W. Singer.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Singer, S.W. A new path for one-carbon conversion. Nat Metab 3, 1286–1287 (2021). https://doi.org/10.1038/s42255-021-00461-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s42255-021-00461-0

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research