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ADIPOSE TISSUE BIOLOGY

Fixing lymphatics improves glucose metabolism

When the ability of lymphatic vessels to transport fluid and macromolecules is perturbed, local adipose tissue often expands. Cao et al. identify destabilized, leaky mesenteric lymphatic vessels in obesity and demonstrate that correcting this dysfunction with a lymphatic-targeting drug improves systemic glucose metabolism.

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Fig. 1: Mesenteric lymphatic integrity affects visceral adipose metabolism.

References

  1. Crewe, C., An, Y. A. & Scherer, P. E. J. Clin. Invest. 127, 74–82 (2017).

    Article  Google Scholar 

  2. Cao, E. et al. Nat. Metab. https://doi.org/10.1038/s42255-021-00457-w (2021).

  3. Cifarelli, V. & Eichmann, A. Cell. Mol. Gastroenterol. Hepatol. 7, 503–513 (2019).

    Article  Google Scholar 

  4. Norden, P. R. & Kume, T. Front. Physiol. 11, 404 (2020).

    Article  Google Scholar 

  5. Jiang, X., Tian, W., Nicolls, M. R. & Rockson, S. G. Front. Physiol. 10, 1402 (2019).

    Article  Google Scholar 

  6. Chakraborty, A. et al. Am. J. Pathol. 189, 924–939 (2019).

    Article  CAS  Google Scholar 

  7. Kuan, E. L. et al. J. Immunol. 194, 5200–5210 (2015).

    Article  CAS  Google Scholar 

  8. Harvey, N. L. et al. Nat. Genet. 37, 1072–1081 (2005).

    Article  CAS  Google Scholar 

  9. Zhang, F. et al. Science 361, 599–603 (2018).

    Article  CAS  Google Scholar 

  10. Vishwakarma, N. et al. AAPS PharmSciTech 20, 83 (2019).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Joseph M. Rutkowski.

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Rutkowski, J.M. Fixing lymphatics improves glucose metabolism. Nat Metab 3, 1139–1141 (2021). https://doi.org/10.1038/s42255-021-00442-3

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