When the ability of lymphatic vessels to transport fluid and macromolecules is perturbed, local adipose tissue often expands. Cao et al. identify destabilized, leaky mesenteric lymphatic vessels in obesity and demonstrate that correcting this dysfunction with a lymphatic-targeting drug improves systemic glucose metabolism.
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Rutkowski, J.M. Fixing lymphatics improves glucose metabolism. Nat Metab 3, 1139–1141 (2021). https://doi.org/10.1038/s42255-021-00442-3
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DOI: https://doi.org/10.1038/s42255-021-00442-3
