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KIDNEY DISEASE

Metabolic reprogramming in polycystic kidney disease explained by super-enhancers and CDK7: new therapeutic targets?

In this issue of Nature Metabolism, Mi and colleagues provide evidence that super-enhancers play a critical role in autosomal-dominant polycystic kidney disease (ADPKD) and show that CDK7 targeting provides a novel therapeutic option.

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Fig. 1: Rearrangement of the SE landscape may account for metabolic reprogramming in ADPKD.

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Acknowledgements

The authors are grateful to A. Mondino and D. Gabellini for critically reading the manuscript. A.B. and L.C. are supported by the Italian Ministry of Health, the PKD Foundation and the Italian Association for Research on Cancer (AIRC).

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Correspondence to Alessandra Boletta.

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A.B. is a co-inventor on two patents for the targeting of cell metabolism in ADPKD.

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Cassina, L., Boletta, A. Metabolic reprogramming in polycystic kidney disease explained by super-enhancers and CDK7: new therapeutic targets?. Nat Metab 2, 659–660 (2020). https://doi.org/10.1038/s42255-020-0232-7

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  • DOI: https://doi.org/10.1038/s42255-020-0232-7

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