Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Metabolic reprogramming in polycystic kidney disease explained by super-enhancers and CDK7: new therapeutic targets?

In this issue of Nature Metabolism, Mi and colleagues provide evidence that super-enhancers play a critical role in autosomal-dominant polycystic kidney disease (ADPKD) and show that CDK7 targeting provides a novel therapeutic option.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Rearrangement of the SE landscape may account for metabolic reprogramming in ADPKD.


  1. Sengupta, S. & George, R. E. Trends Cancer 3, 269–281 (2017).

    Article  CAS  Google Scholar 

  2. Bergmann, C. et al. Nat. Rev. Dis. Primers 4, 50 (2018).

    Article  Google Scholar 

  3. Shillingford, J. M., Piontek, K. B., Germino, G. G. & Weimbs, T. J. Am. Soc. Nephrol. 21, 489–497 (2010).

    Article  CAS  Google Scholar 

  4. Takiar, V. et al. Proc. Natl Acad. Sci. USA 108, 2462–2467 (2011).

    Article  CAS  Google Scholar 

  5. Rowe, I. et al. Nat. Med. 19, 488–493 (2013).

    Article  CAS  Google Scholar 

  6. Podrini, C. et al. Commun Biol 1, 194 (2018).

    Article  Google Scholar 

  7. Padovano, V., Podrini, C., Boletta, A. & Caplan, M. J. Nat. Rev. Nephrol. 14, 678–687 (2018).

    Article  CAS  Google Scholar 

  8. Menezes, L. F., Lin, C. C., Zhou, F. & Germino, G. G. EBioMedicine 5, 183–192 (2016).

    Article  Google Scholar 

  9. Seeger-Nukpezah, T., Geynisman, D. M., Nikonova, A. S., Benzing, T. & Golemis, E. A. Nat. Rev. Nephrol. 11, 515–534 (2015).

    Article  CAS  Google Scholar 

  10. Mi, Z. et al. Nat. Metab. (2020).

    Article  PubMed  Google Scholar 

  11. Pema, M. et al. Nat. Commun. 7, 10786 (2016).

    Article  CAS  Google Scholar 

Download references


The authors are grateful to A. Mondino and D. Gabellini for critically reading the manuscript. A.B. and L.C. are supported by the Italian Ministry of Health, the PKD Foundation and the Italian Association for Research on Cancer (AIRC).

Author information

Authors and Affiliations


Corresponding author

Correspondence to Alessandra Boletta.

Ethics declarations

Competing interests

A.B. is a co-inventor on two patents for the targeting of cell metabolism in ADPKD.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Cassina, L., Boletta, A. Metabolic reprogramming in polycystic kidney disease explained by super-enhancers and CDK7: new therapeutic targets?. Nat Metab 2, 659–660 (2020).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing