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Divide and hide: proliferating β-cells control immune tolerance in autoimmune diabetes

Increasing pancreatic β-cell proliferation in autoimmune type 1 diabetes (T1D) might restore β-cell mass but would be predicted to exacerbate islet inflammation. A study in Nature Metabolism, however, reports that boosting β-cell proliferation in mouse models of T1D is beneficial, preserving the immunological self-tolerance of islets through the induction of regulatory T cells.

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Fig. 1: Highly proliferative β-cells from LIRKO mice show altered identity, induce Treg cells and protect mice from the development of T1D.


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Correspondence to Giuseppe Matarese.

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Galgani, M., Matarese, G. Divide and hide: proliferating β-cells control immune tolerance in autoimmune diabetes. Nat Metab 1, 499–500 (2019).

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