Increasing pancreatic β-cell proliferation in autoimmune type 1 diabetes (T1D) might restore β-cell mass but would be predicted to exacerbate islet inflammation. A study in Nature Metabolism, however, reports that boosting β-cell proliferation in mouse models of T1D is beneficial, preserving the immunological self-tolerance of islets through the induction of regulatory T cells.
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Galgani, M., Matarese, G. Divide and hide: proliferating β-cells control immune tolerance in autoimmune diabetes. Nat Metab 1, 499–500 (2019). https://doi.org/10.1038/s42255-019-0068-1
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DOI: https://doi.org/10.1038/s42255-019-0068-1