Constraining metabolic models by enzyme capacities greatly improves genotype–phenotype predictions. Now, a method for estimating enzyme turnovers based on deep learning has been developed and used to reconstruct enzyme-constrained genome-scale metabolic models for more than 300 yeast species.
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Boorla, V.S., Upadhyay, V. & Maranas, C.D. ML helps predict enzyme turnover rates. Nat Catal 5, 655–657 (2022). https://doi.org/10.1038/s41929-022-00827-x
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DOI: https://doi.org/10.1038/s41929-022-00827-x
