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Homologies between SARS-CoV-2 and allergen proteins may direct T cell-mediated heterologous immune responses


The outbreak of the new severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a public health emergency. Asthma does not represent a risk factor for COVID-19 in several published cohorts. We hypothesized that the SARS-CoV-2 proteome contains T cell epitopes, which are potentially cross-reactive to allergen epitopes. We aimed at identifying homologous peptide sequences by means of two distinct complementary bioinformatics approaches. Pipeline 1 included prediction of MHC Class I and Class II epitopes contained in the SARS-CoV-2 proteome and allergens along with alignment and elaborate ranking approaches. Pipeline 2 involved alignment of SARS-CoV-2 overlapping peptides with known allergen-derived T cell epitopes. Our results indicate a large number of MHC Class I epitope pairs including known as well as de novo predicted allergen T cell epitopes with high probability for cross-reactivity. Allergen sources, such as Aspergillus fumigatus, Phleum pratense and Dermatophagoides species are of particular interest due to their association with multiple cross-reactive candidate peptides, independently of the applied bioinformatic approach. In contrast, peptides derived from food allergens, as well as MHC class II epitopes did not achieve high in silico ranking and were therefore not further investigated. Our findings warrant further experimental confirmation along with examination of the functional importance of such cross-reactive responses.


The World Health Organization (WHO) has declared the outbreak of the new Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2, ssRNA virus, associated with COVID-19) as a public health emergency. As per the WHO report of 20 September 2020, more than 30 million cases and over 950,000 deaths have been reported worldwide1. Human coronaviruses are positive-sense single-stranded RNA (+ ssRNA) viruses, with SARS-CoV-2 and SARS-CoV belonging to the B-lineage of the Betacoronavirus genera and MERS-CoV to the C-lineage of the same genera2,3. The clinical features in patients affected with these respiratory viruses ranges from asymptomatic carriers to severe respiratory illness with pneumonia and acute respiratory distress syndrome (ARDS). In addition, a number of interesting vascular and inflammatory presentations have been noted, including a multisystem inflammatory syndrome in children.

We have previously reported on heterologous immune responses induced by influenza, another respiratory RNA virus, against allergens, which mediated protection from experimental allergic asthma4. Indeed, virus-induced T cell mediated heterologous immunity has been widely described in a variety of settings, which can confer protection or drive immunopathology against other antigens5,6. Given that the host immune response to SARS-CoV-2 and associated disease course can be so varied from patient to patient, this spectrum of presentations raises the question of what drives the differential host immune response. There is still little known about asthma phenotypes and severity of COVID-19. In general, asthma has not been shown to be a risk factor for COVID-19 in several published cohorts7,8. However, recent studies from the UK and the USA indicated higher numbers of asthmatics in COVID-19 patients9.

Interestingly, the UK Biobank recently reported that non-allergic patients had a higher risk of severe COVID-19, compared to patients with allergic asthma10. Moreover, evidence of T cell activation, as indicated by generation of effector (CD45RA-CD62L-) and central memory (CD45RA CD62L+) αβCD4conv and CD8+ cells was reported among COVID-19 patients with mild or severe disease, suggesting that activation of T cells is inversely associated with severity of SARS-CoV-2 infection11. Other investigators reported that T cells in peripheral blood of COVID-19 patients with allergy were increased as compared to patients without allergies12. These preliminary clinical and laboratory observations along with our prior experimental evidence involving RNA viruses led us hypothesize that SARS-CoV-2 may share a degree of protein sequence homology to allergens, which may lead to the generation of cross-reactive T cell epitopes. Pre-existing T cells specific for such cross-reactive allergen-derived epitopes may have an impact on COVID-19 outcome via aberrant cytokine responses to the virus peptides. Indeed, these cytokines could prevent an overshooting T1 inflammatory reaction, both locally (as in the case of preexisting pulmonary CD4+ T cells specific to inhalant allergens) and/or systemically. Therefore, we sought to predict potentially cross-reactive allergen- and SARS-CoV-2-derived MHC Class I and Class II T cell epitopes, which can be presented by the most prevalent HLA alleles.

Methods and results

In order to examine our working hypothesis, we applied two distinct independent, complementary and systematic bioinformatics approaches (Fig. 1): (a) Pipeline 1-prediction of MHC Class I and Class II epitopes contained in the SARS-CoV-2 proteome and a comprehensive set of allergen protein sequences combined with alignment strategies and ranking of results based on clinical and sequence conservation criteria and (b) Pipeline 2- alignment of SARS-CoV-2 overlapping peptides with known allergen-derived T cell epitopes13.

Figure 1
figure 1

Schematic overview of the bioinformatics approaches. A Pipeline 1; SARS-CoV-2 proteins were aligned against > 2500 allergen protein sequences (see methods) and MHC class I-and II- restricted potentially cross-reactive T cell epitope pairs were identified for the most frequent human HLA alleles. B Pipeline 2; In an independent framework, we performed the comparative analysis of sequential kmers from SARS-CoV-2 protein sequences with known IEDB allergen peptides to predict the cross-reactive viral peptide pool.

Pipeline 1

More than > 2500 allergen protein sequences were downloaded (dates of access 10.09.2017) from Allergome14,15,16,17 (Supplementary Table S1), and protein sequences for SARS-CoV-2 from UniProt18 (Supplementary Table S2). Viral T cell epitope prediction was performed using smm19, ann20 and consensus21 for MHC Class I (IC50 threshold <  = 5000), and netMHCII22 for MHC Class II (affinity score threshold for strong binders: 0.500; for weak binders: 2.000) (Supplementary Table S3). Epitopes predicted by all methods were aligned against all allergen proteins using a local version of the NCBI protein blast program23. Allergen proteins associated with an alignment e-value < 10 were further processed for T cell epitope prediction using netMHC24 and netMHCpan25 for MHC Class I, and netMHCII and netMHCIIpan26 for MHC Class II prediction (affinity score threshold for strong binders: 0.500; for weak binders: 2.000). Viral and allergen epitopes were pairwise aligned with Biopython module pairwise 227 and for pairs with a score > 8, a final pair combined score (pcs) was calculated (Supplementary Methods). A higher pair combined score indicates a higher chance for a peptide pair to be cross-reactive and binding to MHC molecules. Duplicates among the resulting candidate epitope pairs were removed before further processing. Therefore, possible sequence repetition due to isoforms and isoallergens (Supplementary Table S1) do not influence further analyses. In total, we obtained more than 5000 candidate pairs for each, MHC Class I and Class II. The top 30 candidate epitope pairs, as per pair combined score, are listed for aero- and food allergens, MHC Class I and Class II presentation background in Supplementary Tables S4S7, respectively. The top 30 MHC Class II restricted predicted virus-allergen pairs achieved relatively low pcs (24–657) as compared to Class I epitope pairs (1036–10,816). Among our top 30 MHC Class I potentially cross-reactive allergen derived epitopes, we identified more than 20 distinct protein families (Allfam database). In addition to MHC binding affinity and homology between peptide sequences, also other factors (e.g. conservation, association with clinical reactions) are important for the clinical relevance of peptides predicted to be cross-reactive at the T cell level. In order to capture this information level in our ranking, all allergen peptides and associated sources listed among the top 30 candidate epitope pairs were evaluated further with a scoring system (Supplementary Fig. S1 and Supplementary Methods). We found that the top 5 Class I aeroallergens were on average associated with higher pcs as compared to the top 5 potentially cross-reactive food allergens (Table 1 for MHC Class I and Table 2 for MHC Class II peptide pairs).

Table 1 The Top 5 candidate human HLA class I T cell potentially cross-reactive epitope pairs between SARS-CoV-2 and aero-and food-allergens based on pair combined score and application of additional clinical and conservation related criteria (see Suppl. Fig. 1) (pipeline 1).
Table 2 The Top 5 candidate human HLA class II T cell potentially cross-reactive epitope pairs between SARS-CoV-2 and aero-and food-allergens based on pair combined score and application of additional clinical and conservation related criteria (see Fig. 1) (pipeline 1) Pcs = pair combined score.

Pipeline 2

We obtained all known allergen-derived linear T cell epitope peptides from the IEDB, containing peptides known to bind MHC molecules with at least one published experimental evidence (e.g. based on the results of a T cell assay) (Supplementary Table S8). A total of 8207 antigenic peptides from 142 antigens were selected for evaluation, among which, peptides with ambiguous amino acids (e.g. with unknown amino acid ‘X’ or any special character) were removed from the subsequent analysis. Therefore, all included peptides could be defined in full. Next, SARS-CoV-2 protein sequences were analyzed for the potential antigenic regions by splitting each of the sequence into sequential k-mers (length = 15), and homology with allergen antigenic peptides was then profiled. Within a given threshold range, we found 43 unique SARS-CoV-2 peptides that belong to replicase poly protein and spike glycoprotein (Supplementary Table S9). These peptides demonstrate homology with antigenic peptides of 6 different allergen sources, including Canis lupus, Dermatophagoides farinae, Dermatophagoides pteronyssinus, Aspergillus fumigatus, Alternaria alternata and Phleum pratense, all of which are known to be respiratory allergens and, in the majority, clinically highly relevant (e.g. aeroallergens; Fig. 1).

However, despite the homology, it is likely that some of the peptides may not have strong MHC Class I binding affinity, and thus be less likely to be presented as antigens by HLA molecules. Therefore, we assessed the binding affinity of these peptides with human MHC Class I molecules, across a broad range of alleles that are known to bind viral proteins (52 most common HLA-A and HLA-B alleles). We observed that some of these peptides (n = 79) were predicted to have MHC Class I binding epitope regions associated with at least one of the Class I HLA alleles with IC50 < 500 nm (Supplementary Table S10). These antigenic peptides were predicted to bind with 20 most frequently occurring HLA Class I alleles, in which HLA*02:03 and HLA*02:06 were predicted to present the highest number of epitope residues. To further investigate if these peptides are specific to the coronavirus family, we performed the BLAST comparison with 2807 known viral antigenic peptides of bacteria, influenza-and corona- virus family (non-SARS CoV-2) from IEDB (with at least one T cell assay evidence) and filtered out matching peptides (Blast e-value < 1 and identity > 70%). Finally, we present 48 high-affinity HLA-binding peptides which are unique to the SARS-CoV-2 proteome, not common to bacteria, influenza and corona virus family antigenic peptides within a given threshold range (Supplementary Table S11) with 14 high confidence HLA Class I binding peptides with IC50 < 50 nm (Table 3).

Table 3 HLA-I binding high confidence (IC50 < 50 nm) SARS-CoV-2 antigenic peptides (pipeline 2).

Application of both complementary pipelines aimed at identifying T cell epitope pairs, which are highly likely to be cross-reactive. Pipeline 1 includes a broader approach by means of considering as many allergen protein sequences are available and subsequently predicting MHC binding affinity and performing alignment of the candidate epitopes. The elaborate scoring system which followed, prioritized these candidates based on clinical aspects and thus relevance. This pipeline has already been used and experimentally validated by our group for similar analyses (Balz K. et al., unpublished data). Nevertheless, immunogenicity and cross-reactivity of the peptides identified by pipeline 1 in our index work remains to be shown. Pipeline 2 takes only known immunogenic peptides into consideration, leading to more robust results. Further, alignment of these epitopes against the proteome of other organisms, allows identification of epitopes, which are unique for SARS-CoV-2. The approach of pipeline 2, however, does not allow identification of newly described T cell epitopes and less studied allergens are not considered.


We have applied two independent, complementary and systematic bioinformatic approaches in order to identify potentially cross-reactive allergen- and SARS-CoV-2- T cell epitopes. Our in silico analysis revealed numerous candidate epitope pairs, including previously published and predicted peptides, while both applied pipelines highlighted an important role of MHC class I inhalant allergens. Epitope pairs including peptides from food allergens appeared to be of lower importance. Our finding may indicate that patients with respiratory allergies including asthma may be more affected by heterologous immune response against SARS-CoV-2. It is of high relevance, that both pipelines highlighted candidate epitopes from Dermatophagoides species, as well as Aspergillus fumigatus and Phleum pratense, suggesting an important role for these allergens. Although the frequency of allergen-specific CD8+ T cells is likely to be low, rare cell subsets have been quite often shown to play an important pathophysiological role28, and new technologies and bioinformatic approaches for identification of such populations are steadily emerging29. Quite importantly, the SARS-CoV-2 Nsp6141-149, which was identified among our top potentially cross-reactive epitope pairs, has been recently described by an independent group30. To our knowledge, this is the first report on in silico predicted T cell epitope cross-reactivity between SARS-CoV-2 and allergens. While a limitation of our study is the in silico nature of the work, the sequence homology between SARS-CoV-2 and clinically relevant respiratory allergens is along the lines of previously reported cross-reactivity between RNA virus- and allergen-derived peptides at the level of T memory cells4. Moreover, our current findings generate further hypotheses in how the adaptive immune system responds differentially with respect to the atopy status of the host. Our present study warrants an immediate investigation of these predicted T cell epitopes to link their possible role in driving the immune response against the SARS-CoV-2 and eventually shape COVID-19 outcome.

There are several different avenues through which the similarities may influence the host immune response. For instance, in hosts sensitized to one of the predicted aeroallergens, the identified similarities with the SARS-CoV-2 proteome may be protective if they prevent an overwhelming Th1 response and the accompanying cytokine storm. Furthermore, allergen-specific T cells may develop a memory response against heterologous SARS-CoV-2 epitopes, which is faster and more efficient. Conversely, such heterologous immune responses could have an adverse outcome by attenuating the antiviral response. T2 immune bias could potentially lead to inadequate virus clearance due to attenuated CD8+ responses. Indeed, there is evidence of a reciprocal relationship between atopy and production of type I and III Interferons in response to viral infections31. Given that underlying atopic conditions have not been identified as a significant risk factor for severe clinical courses in those infected with SARS-CoV-2, the epitope homology most likely plays a protective role7,8. Interestingly, Jackson et al32 recently reported that nasal epithelial cells from children with atopic asthma express significantly lower levels of ACE2 receptor as compared to cells from children without asthma or with non-atopic asthma. Similarly, another study using adult bronchial brush samples showed an inverse correlation between ACE2 gene expression and a Th2 dependent gene expression signature33. Differential expression of ACE2 receptors among atopic individuals could represent a distinct and unrelated mechanism of action in this context. Our in silico data provide ground to investigate the role of cellular immune responses in regards to the interaction between atopy/asthma and COVID-19. Indeed, the role of SARS-CoV-2-specific T cells in exposed and non-exposed individuals, thereby underlining the importance of heterologous immunity, has been very recently described34,35. Further experimental studies are needed to explore the involved pathogenetic mechanisms and potential clinical implications of underlying aeroallergen sensitization on the immune response to SARS-CoV-2.

Data availability

The data used and analyzed in the present study are available from the corresponding author on reasonable request.



Angiotensin converting enzyme 2


Acute respiratory distress syndrome


Basic local alignment search tool


Human leukocyte antigen


Immune epitope database


Major histocompatibility complex


National Center for Biotechnology Information


Ribonucleic acid


Positive-sense single-stranded RNA

Th 1:

T-helper 1

Th 2:

T-helper 2


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CS is supported by the Universities Giessen and Marburg Lung Center (UGMLC), the German Center for Lung Research (DZL), University Hospital Giessen and Marburg (UKGM) research funding according to article 2, section 3 cooperation agreement, and the Deutsche Forschungsgemeinschaft (DFG)-funded SFB 1021 (C04), KFO 309 (P10), and SK 317/1-1 (Project No. 428518790) as well as by the Foundation for Pathobiochemistry and Molecular Diagnostics. KCN is supported by NIH Grants U01AI140498-03 and R01AI140134-01, The Sunshine Foundation, and the Sean N. Paker Center for Allergy and Asthma Research at Stanford University.


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Conception or design of the work: C.S., K.C.N.; Data collection: K.B., A.K., F.C., V.H.; Data analysis and interpretation: C.S., K.C.N., K.B., A.K., P.T., N.T., K.E., P.N.; Drafting the article: C.S., K.C.N., K.B., M.C., A.K.; Critical revision of the article: C.S., K.C.N., K.B., M.C., A.K., H.R.; Final approval of the version to be published: All.

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Correspondence to Chrysanthi Skevaki.

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Competing interests

For CS: Consultancy and research funding, Hycor Biomedical, Bencard Allergie and Thermo Fisher Scientific; Research Funding, Mead Johnson Nutrition (MJN). For KCN: Dr. Nadeau reports Grants from National Institute of Allergy and Infectious Diseases (NIAID), Food Allergy Research & Education (FARE), End Allergies Together (EAT), Allergenis, and Ukko Pharma; Grant awardee at NIAID, National Institute of Environmental Health Sciences (NIEHS), National Heart, Lung, and Blood Institute (NHLBI), and the Environmental Protection Agency (EPA); is involved in Clinical trials with Regeneron, Genentech, AImmune Therapeutics, DBV Technologies, AnaptysBio, Adare Pharmaceuticals, and Stallergenes-Greer; Research Sponsorship by Novartis, Sanofi, Astellas, Nestle; Data and Safety Monitoring Board member at Novartis and NHLBI; Cofounded Before Brands, Alladapt, ForTra, and Iggenix; Chief Intellectual Office at FARE, Director of the World Allergy Organization (WAO) Center of Excellence at Stanford, Personal fees from Regeneron, Astrazeneca, ImmuneWorks, and Cour Pharmaceuticals; Consultant and Advisory Board Member at European Academy of Allergy and Clinical Immunology (EAACI) Research and Outreach Committee, Ukko, Before Brands, Alladapt, IgGenix, Probio, Vedanta, Centecor, Seed, Novartis, NHBLI, EPA, National Scientific Committee of Immune Tolerance Network (ITN) and NIH Programs; US patents for basophil testing, multifood immunotherapy and prevention, monoclonal antibody from plasmoblasts, and device for diagnostics. All other authors have no competing interests to declare.

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Balz, K., Kaushik, A., Chen, M. et al. Homologies between SARS-CoV-2 and allergen proteins may direct T cell-mediated heterologous immune responses. Sci Rep 11, 4792 (2021).

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