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Natural killers of cognition

One of the mechanisms driving aging and neurodegenerative diseases is the accumulation of senescent cells, while their elimination mitigates age-related decline. A new report details how, with aging, changes in the dentate gyrus microenvironment lead to natural-killer-cell-mediated clearance of neurogenic senescent cells, resulting in cognitive decline.

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Fig. 1: Elimination of senescent cells in normal aging and in neurodegenerative diseases.


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Correspondence to Valery Krizhanovsky.

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V.K. is an author of patents in the field of senescence and senolytics.

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Papismadov, N., Krizhanovsky, V. Natural killers of cognition. Nat Neurosci 24, 2–4 (2021).

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