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AGING

Natural killers of cognition

One of the mechanisms driving aging and neurodegenerative diseases is the accumulation of senescent cells, while their elimination mitigates age-related decline. A new report details how, with aging, changes in the dentate gyrus microenvironment lead to natural-killer-cell-mediated clearance of neurogenic senescent cells, resulting in cognitive decline.

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Fig. 1: Elimination of senescent cells in normal aging and in neurodegenerative diseases.

References

  1. Jin, W.-N. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-020-00745-w (2020).

  2. Gorgoulis, V. et al. Cell 179, 813–827 (2019).

    CAS  Article  Google Scholar 

  3. Muñoz-Espín, D. & Serrano, M. Nat. Rev. Mol. Cell Biol. 15, 482–496 (2014).

    Article  Google Scholar 

  4. Ovadya, Y. et al. Nat. Commun. 9, 5435 (2018).

    CAS  Article  Google Scholar 

  5. Baker, D. J. et al. Nature 530, 184–189 (2016).

    CAS  Article  Google Scholar 

  6. Ziv, Y. et al. Nat. Neurosci. 9, 268–275 (2006).

    CAS  Article  Google Scholar 

  7. Radjavi, A., Smirnov, I., Derecki, N. & Kipnis, J. Mol. Psychiatry 19, 531–533 (2014).

    CAS  Article  Google Scholar 

  8. Chinta, S. J. et al. Cell Rep. 22, 930–940 (2018).

    CAS  Article  Google Scholar 

  9. Zhang, P. et al. Nat. Neurosci. 22, 719–728 (2019).

    CAS  Article  Google Scholar 

  10. Jurk, D. et al. Aging Cell 11, 996–1004 (2012).

    CAS  Article  Google Scholar 

  11. Lugert, S. et al. Cell Stem Cell 6, 445–456 (2010).

    CAS  Article  Google Scholar 

  12. Sagiv, A. & Krizhanovsky, V. Biogerontology 14, 617–628 (2013).

    CAS  Article  Google Scholar 

  13. Krizhanovsky, V. et al. Cell 134, 657–667 (2008).

    CAS  Article  Google Scholar 

  14. Ovadya, Y. & Krizhanovsky, V. J. Clin. Invest. 128, 1247–1254 (2018).

    Article  Google Scholar 

  15. Ron-Harel, N. & Schwartz, M. Trends Neurosci. 32, 367–375 (2009).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Valery Krizhanovsky.

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V.K. is an author of patents in the field of senescence and senolytics.

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Papismadov, N., Krizhanovsky, V. Natural killers of cognition. Nat Neurosci 24, 2–4 (2021). https://doi.org/10.1038/s41593-020-00749-6

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