The creation of a murine Cre driver specific to CNS capillary pericytes has opened a major bottleneck in brain microvascular research. Using this tool, pericyte loss in the adult brain is shown to induce neuronal loss due to concurrent microcirculatory failure and depletion of the protective trophic factor pleiotrophin.
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Berthiaume, AA., Shih, A.Y. Sharpening the tools for pericyte research. Nat Neurosci 22, 1041–1043 (2019). https://doi.org/10.1038/s41593-019-0437-9
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DOI: https://doi.org/10.1038/s41593-019-0437-9