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Ophthalmology

Rejuvenation of diabetic macular edema with senolytic therapy

Nature Medicine volume 30, pages 346–347 (2024)Cite this article

Senolytic therapy for diabetic macular edema (DME) refractory to anti-VEGF treatment appears safe, and preliminary data suggest a therapeutic effect on visual acuity and macular thickness.

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Fig. 1: Senolytic therapy as a new option for diabetic macular edema.

References

  1. Teo, Z. L. et al. Ophthalmology 128, 1580–1591 (2021).

    Article  PubMed  Google Scholar 

  2. Ciulla, T. A., Pollack, J. S. & Williams, D. F. Br. J. Ophthalmol. 105, 216–221 (2021).

    Article  PubMed  Google Scholar 

  3. Wykoff, C. C. et al. Lancet 399, 741–755 (2022).

    Article  CAS  PubMed  Google Scholar 

  4. Crespo-Garcia, S. et al. Nat. Med. https://doi.org/10.1038/s41591-024-02802-4 (2024).

    Article  PubMed  Google Scholar 

  5. Antonetti, D. A., Silva, P. S. & Stitt, A. W. Nat. Rev. Endocrinol. 17, 195–206 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Oshitari, T. Int. J. Mol. Sci. 24, 12919 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Gorgoulis, V. et al. Cell 179, 813–827 (2019).

    Article  CAS  PubMed  Google Scholar 

  8. Liu, H. et al. JCI Insight 8, e168945 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  9. El-Nimri, N. W. et al. Sci. Rep. 10, 21752 (2020).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  10. Wong, F., Omori, S., Donghia, N. M., Zheng, E. J. & Collins, J. J. Nat. Aging 3, 734–750 (2023).

    Article  CAS  PubMed  Google Scholar 

  11. Cordeiro, M. F. et al. Prog. Retin. Eye Res. 86, 100976 (2022).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan

    Tomoaki Murakami

  2. Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, MI, USA

    Thomas W. Gardner

Authors
  1. Tomoaki Murakami
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  2. Thomas W. Gardner
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Correspondence to Tomoaki Murakami or Thomas W. Gardner.

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Murakami, T., Gardner, T.W. Rejuvenation of diabetic macular edema with senolytic therapy. Nat Med 30, 346–347 (2024). https://doi.org/10.1038/s41591-024-02804-2

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