We transplanted gene-edited porcine hearts into two brain-dead human recipients, then evaluated their cardiac function and immune response over the following 66 hours. Both hearts showed sustained cardiac function over the course of the study, without evidence of hyperacute rejection or zoonotic transmission.
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References
Griesemer, A., Yamada, K. & Sykes, M. Xenotransplantation: immunological hurdles and progress towards tolerance. Immunol. Rev. 258, 241–258 (2014). A review article that presents the immunological and physiological barriers to xenotransplantation.
Montgomery, R. A. et al. Results of two cases of pig-to-human kidney xenotransplantation. N. Engl. J. Med. 386, 1889–1898 (2022). This paper reports the first pig-to-human kidney xenotransplants performed in brain-dead human decedents.
Griffith, B. P. et al. Genetically modified porcine-to-human cardiac xenotransplantation. N. Engl. J. Med. 387, 35–44 (2022). This paper reports the first pig-to-human heart xenotransplant in a living human recipient.
Mohiuddin, M. M. et al. Progressive genetic modifications of porcine cardiac xenografts extend survival to 9 months. Xenotransplantation 29, e12744 (2022). This paper reports the longest surviving pig-to-non-human primate cardiac xenotransplantation using a 10GE xenograft heart.
Mehta, S. A. et al. Infection and clinical xenotransplantation: guidance from the Infectious Disease Community of Practice of the American Society of Transplantation. Am. J. Transplant. 23, 309–315 (2023). This paper presents clinical guidance on infectious control practices to prevent zoonotic transmission.
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This is a summary of: Moazami, N. et al. Pig-to-human heart xenotransplantation in two recently deceased human recipients. Nat. Med. https://doi.org/10.1038/s41591-023-02471-9 (2023).
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Porcine heart xenotransplantation in brain-dead decedents. Nat Med 29, 1918–1919 (2023). https://doi.org/10.1038/s41591-023-02493-3
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DOI: https://doi.org/10.1038/s41591-023-02493-3
