A phase 2 study fails to meet its primary endpoint, but the treatment — a glucagon receptor antagonist — shows clinically relevant improvements in glycemic control, warranting further investigation as a potential adjunct to insulin.
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References
Foster, N. C. et al. Diabetes Technol Ther. 21, 66–72 (2019).
Pettus, J. et al. Nat. Med. https://doi.org/10.1038/s41591-022-02011-x (2022).
Unger, R. H. & Orci, L. Proc. Natl Acad. Sci. USA 107, 16009–16012 (2010).
Brown, R. J., Sinaii, N. & Rother, K. I. Diabetes Care 31, 1403–1404 (2008).
Sherr, J. et al. Diabetes Care 37, 1741–1744 (2014).
Gerich, J. E. et al. Science 182, 171–173 (1973).
Pearson, M. J., Unger, R. H. & Holland, W. L. Diabetes Care 39, 1075–1077 (2016).
Kelly, R. P. et al. Diabetes Obes. Metab. 17, 414–422 (2015).
Pettus, J. et al. Diabetes Obes. Metab. 20, 1302–1305 (2018).
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M.A.V. reports research support from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and Provention Bio. J.L.S. reports research support from the Juvenile Diabetes Research Foundation, Insulet, Medtronic and NIDDK; has served on advisory boards for Bigfoot Biomedical, Cecelia Health, Insulet, Medtronic Diabetes, StartUp Health Diabetes Moonshot and Vertex; and has done consulting work for Cecelia Health, Eli Lilly, Insulet, Medtronic and Zealand.
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Van Name, M., Sherr, J. When insulin isn’t enough: targeting glucagon in type 1 diabetes. Nat Med 28, 2007–2008 (2022). https://doi.org/10.1038/s41591-022-02019-3
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DOI: https://doi.org/10.1038/s41591-022-02019-3