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CCR5-∆32 is deleterious in the homozygous state in humans

Abstract

We use the genotyping and death register information of 409,693 individuals of British ancestry to investigate fitness effects of the CCR5-∆32 mutation. We estimate a 21% increase in the all-cause mortality rate in individuals who are homozygous for the ∆32 allele. A deleterious effect of the ∆32/∆32 mutation is also independently supported by a significant deviation from the Hardy–Weinberg equilibrium (HWE) due to a deficiency of ∆32/∆32 individuals at the time of recruitment.

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Acknowledgements

The authors thank D. Feehan, M. Slatkin, and P. Wilton for discussions about death rate estimation, and R. Durbin, C. Freeman, and G. McVean for discussions about UK Biobank markers. This work is supported by US National Institutes of Health (NIH) grant R01GM116044 to R.N.

Author information

X.W. and R.N. designed the study and wrote the manuscript. X.W. analyzed the data.

Competing interests

The authors declare no competing interests.

Correspondence to Xinzhu Wei or Rasmus Nielsen.

Extended data

  1. Extended Data Fig. 1 The deviation from HWE with age.

    a, The observed deviation using age at recruitment estimated. Each dot represents one age group. The grey error bars show the 95% confidence intervals estimated from bootstrap the genotypes of individuals recruited at each age 1000 times. The sample size used for each error bar ranges from 15191 to 100117 with a mean of 65479. b, The predicted deviation from HWE using the corrected survival probability. A total of 395704 samples are used. The observed and predicted values are significantly correlated (Spearman’s correlation coefficient ρ= 0.67, P= 1.4 × 10−4).

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Fig. 1: CCR5-∆32 is deleterious in the homozygous state.
Extended Data Fig. 1: The deviation from HWE with age.