Intestinal microbial dysbiosis has been described in individuals with an HIV-1 infection and may underlie persistent inflammation in chronic infection, thereby contributing to disease progression. Herein, we induced an HIV-1-like intestinal dysbiosis in rhesus macaques (Macaca mulatta) with vancomycin treatment and assessed the contribution of dysbiosis to SIV disease progression. Dysbiotic and control animals had similar disease progression, indicating that intestinal microbial dysbiosis similar to that observed in individuals with HIV is not sufficient to accelerate untreated lentiviral disease progression.
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Ortiz, A. M. & Brenchley, J. M. Curr. Opin. HIV AIDS 13, 15–21 (2018).
Brenchley, J. M., Silvestri, G. & Douek, D. C. Immunity 32, 737–742 (2010).
Noguera-Julian, M. et al. EBioMedicine 5, 135–146 (2016).
Policicchio, B. B., Pandrea, I. & Apetrei, C. Front. Immunol. 7, 12 (2016).
Mudd, J. C. & Brenchley, J. M. J. Infect. Dis. 214 Suppl 2, S58–S66 (2016).
Ivanov, I. I. et al. Cell 139, 485–498 (2009).
Kelly, C. J. et al. Cell Host Microbe 17, 662–671 (2015).
Day, C. L. et al. Nature 443, 350–354 (2006).
Betts, M. R. et al. Blood 107, 4781–4789 (2006).
McKenna, P. et al. PLoS Pathog. 4, e20 (2008).
Gosmann, C. et al. Immunity 46, 29–37 (2017).
d’Ettorre, G. et al. Immun. Inflamm. Dis. 5, 244–260 (2017).
Vujkovic-Cvijin, I. et al. Gut Microbes 8, 440–450 (2017).
Hager, C. L. & Ghannoum, M. A. Curr. Opin. HIV AIDS 13, 69–72 (2018).
Ortiz, A. M. et al. Mucosal Immunol. 9, 458–467 (2016).
Caporaso, J. G. et al. Nat. Methods 7, 335–336 (2010).
Langille, M. G. et al. Nat. Biotechnol. 31, 814–821 (2013).
Estes, J. D. et al. PLoS Pathog. 6, e1001052 (2010).
Hao, X. P. et al. Nat. Commun. 6, 8020 (2015).
Brenchley, J. M. et al. Blood 120, 4172–4181 (2012).
Segata, N. et al. Genome Biol. 12, R60 (2011).
Parks, D. H., Tyson, G. W., Hugenholtz, P. & Beiko, R. G. Bioinformatics 30, 3123–3124 (2014).
We would like to acknowledge H. Kendall, J. Swerczek, R. Herbert, and all the veterinary staff at the NIH animal center. We would like to thank M. Quiñones, J. Davis, S. Sen and G. Trinchieri, and the NIAID Microbiome Program for technical and analytical assistance. Funding for this study was provided in part by the Division of Intramural Research/NIAID/NIH, by the Oregon National Primate Research Center NIH grant award P51OD011092, and with federal funds from the National Cancer Institute, NIH, under Contract No. HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services (DHHS), nor does the mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.
The authors declare no competing interests.
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Ortiz, A.M., Flynn, J.K., DiNapoli, S.R. et al. Experimental microbial dysbiosis does not promote disease progression in SIV-infected macaques. Nat Med 24, 1313–1316 (2018). https://doi.org/10.1038/s41591-018-0132-5
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