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NEURODEGENERATION

Fire prevention in the Parkinson’s disease brain

A glucagon-like peptide receptor 1 (GLP-1R) agonist inhibits the conversion of astrocytes into a neurotoxic phenotype and protects against neurodegeneration, shedding light on the pathogenesis of Parkinson’s disease.

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Fig. 1: GLP1-R agonists act on glial cells to protect dopamine neurons from death.

Marina Spence/Springer Nature

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Correspondence to Patrik Brundin.

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Brundin, L., Bergkvist, L. & Brundin, P. Fire prevention in the Parkinson’s disease brain. Nat Med 24, 900–902 (2018). https://doi.org/10.1038/s41591-018-0109-4

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