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Baseline immune characteristics linked to pneumococcal vaccine responsiveness in older adults

Nature Immunology volume 25, pages 198–199 (2024)Cite this article

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The effectiveness of pneumococcal vaccines declines with age for unknown reasons. We studied the responses of older adults to the 23-valent PPSV23 and the 13-valent PCV13, identifying distinct baseline immune characteristics associated with vaccine responsiveness, including a cytotoxicity signature associated with weaker responses to PCV13.

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Fig. 1: Baseline immune characteristics associated with pneumococcal vaccine responsiveness.

References

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This is a summary of: Ravichandran, S. et al. Distinct baseline immune characteristics associated with responses to conjugated and unconjugated pneumococcal polysaccharide vaccines in older adults. Nat. Immunol. https://doi.org/10.1038/s41590-023-01717-5 (2024).

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Baseline immune characteristics linked to pneumococcal vaccine responsiveness in older adults. Nat Immunol 25, 198–199 (2024). https://doi.org/10.1038/s41590-023-01737-1

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