Using high-resolution molecular and optical mapping of the three-dimensional genome, we found that the transcription factor TCF-1 is linked to changes in the structure of topologically associating domains in T cell progenitors that lead to interactions between previously insulated regulatory elements and target genes at late stages of T cell development.
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This is a summary of: Wang, W. et al. TCF-1 promotes chromatin interactions across topologically associating domains in T cell progenitors. Nat. Immunol. https://doi.org/10.1038//s41590-022-01232-z (2022).
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TCF-1 mediates chromatin intermingling during T cell development. Nat Immunol 23, 1000–1001 (2022). https://doi.org/10.1038/s41590-022-01237-8